Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus
文献类型：期刊论文
| 作者 | Ji Chao; Li Qing; Aisa HajiAkber ; Yang Nan; Dong Yi-Long; Liu Yan-Yong; Wang Tao; Hao Qiang; Zhu Hai-Bo; Zuo Ping-Ping
|
| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2009 |
| 卷号 | 16期号:2页码:331-339 |
| 关键词 | Alzheimer's disease apoptosis regulatory proteins calbindin Gossypium herbaceam ibotenic acid |
| ISSN号 | 1387-2877 |
| 英文摘要 | Excitotoxicity is one of the most extensively studied processes of neuronal death and plays an important role in Alzheimer's disease. In the present study, the protective effects of Gossypium herbaceam extracts (GHE) on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze. Furthermore, neuroprotective effects of GHE were investigated with methods of immunohistochemistry and biochemistry. Our data showed that oral administration with GHE at the doses of 35, 70 and 140 mg/kg exerted an improved effect on the learning and memory impairment in rats induced by intracerebral injection of ibotenic acid. To confirm the precise mechanism of memory improvement by presence of GHE, we further investigated the potential protection on the hippocampus. Our findings suggest that GHE afforded a beneficial inhibition on pro-apoptosis proteins expression following ibotenic acid. Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. These data suggested that GHE could be a potential agent for preventing or retarding the development or progression of Alzheimer's disease. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000264288800011 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/1890]  |
| 专题 | 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Dept Pharmacol, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China;Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji Chao,Li Qing,Aisa HajiAkber,et al. Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus[J]. JOURNAL OF ALZHEIMERS DISEASE,2009,16(2):331-339. |
| APA | Ji Chao.,Li Qing.,Aisa HajiAkber.,Yang Nan.,Dong Yi-Long.,...&Zuo Ping-Ping.(2009).Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus.JOURNAL OF ALZHEIMERS DISEASE,16(2),331-339. |
| MLA | Ji Chao,et al."Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus".JOURNAL OF ALZHEIMERS DISEASE 16.2(2009):331-339. |
入库方式： OAI收割
来源：新疆理化技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。