A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin
文献类型：期刊论文
| 作者 | Yun Qiang; He Minglei; Xing Wenchao; Bi Jingxiu; Ma Guanghui; Su Zhiguo |
| 刊名 | Biotechnology Letters
 |
| 出版日期 | 2004 |
| 卷号 | 26期号:17页码:1359-1363 |
| 关键词 | blood substitute bovine hemoglobin cross-linking reagent modification |
| ISSN号 | 1415492 |
| 英文摘要 | A novel tetrafunctional reagent, α,γ,α′, γ′-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSu)4), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoglobin showed a slight decrease in half-saturated O2 pressure value (P50, from 28.1 mm Hg to 21.7 mm Hg) and Hill coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O2 delivery. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000225103700008 |
| 公开日期 | 2012-11-29 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/2221]  |
| 专题 | 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem |
| 推荐引用方式 GB/T 7714 | Yun Qiang,He Minglei,Xing Wenchao,et al. A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin[J]. Biotechnology Letters,2004,26(17):1359-1363. |
| APA | Yun Qiang,He Minglei,Xing Wenchao,Bi Jingxiu,Ma Guanghui,&Su Zhiguo.(2004).A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin.Biotechnology Letters,26(17),1359-1363. |
| MLA | Yun Qiang,et al."A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin".Biotechnology Letters 26.17(2004):1359-1363. |
入库方式： OAI收割
来源：新疆理化技术研究所
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