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  2. 合肥物质科学研究院
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  4. 中科院强磁场科学中心
Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy

文献类型：期刊论文

作者Wang, Dan3; Lin, Haiyan2; Zhang, Guilong5; Si, Yuanchun3; Yang, Hongyi4; Bai, Guo1,6; Yang, Chi1,6; Zhong, Kai4; Cai, Dongqing5; Wu, Zhengyan5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2018-09-19
卷号10期号:37页码:31114-31123
关键词pH-activated synchronous MRI theranostic platform tumor chemotherapy
ISSN号1944-8244
DOI10.1021/acsami.8b11408
通讯作者Wang, Renfei(hzwrf@163.com) ; Zou, Duohong(zouduohong@126.com)
英文摘要Current magnetic resonance imaging (MRI)-guided pH-switching therapeutic platforms have encountered problems such as low relaxation rates, poor pH-switching efficiencies, and a lag in the drug release behind the MRI. Herein, we designed a nanoplatform with tunable pore size, which could match the size of drug molecules for pH-switching MRI and chemotherapy via ultrasmall manganese oxide-capped mesoporous silica nanoparticles (USMO@MSNs). USMO@MSN could quickly dissolve under weakly acidic conditions and leach abundant Mn2+ ions (leaching ratio: 76%), enhancing the MR contrast. The longitudinal relaxation rate (r(1)) of USMO@MSNs significantly increased from 0.65 to 5.61 mM(-1) s(-1) as the pH decreased from 7.4 to 4.5, showing an ultrahigh-efficiency pH-switching T-1-weighted MR contrast ability for in vivo tumor. Meanwhile, the matching pore structure allowed effective loading of doxorubicin (DOX) on USMO@MSNs to form smart therapeutic system (USMO@MSNs-DOX). The DOX release rate was strongly proportional to the pH-switching MRI signal of USMO@MSNs-DOX, allowing the release of DOX to be efficiently monitored by MRI. Confocal observations indicated that USMO@MSNs-DOX could be effectively internalized by HSC3 cells, and the entire system showed a good pH-switching theranostic performance for HSC3 cells. Therefore, this simple pH-switching system provides a new avenue for timely cancer diagnosis and personalized therapy.
WOS关键词DRUG-DELIVERY SYSTEM ; MRI CONTRAST AGENTS ; MESOPOROUS SILICA ; BIOIMAGING AGENT ; CARRIER SYSTEM ; TUMOR ACIDITY ; T-1 CONTRAST ; NANOPARTICLES ; GADOLINIUM ; DENDRIMER
资助项目National Natural Science Foundation of China[21407151] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province[17030701051] ; Natural Science Foundation of Anhui Province[1808085MB38] ; Zhejiang Characteristic Discipline[2014-112-01] ; Zhejiang Provincial Health Science and Technology Project[2017H011]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000445439900022
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/39002]  
专题合肥物质科学研究院_中科院强磁场科学中心
合肥物质科学研究院_技术生物与农业工程研究所
通讯作者Wang, Renfei; Zou, Duohong
作者单位1.Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Natl Clin Res Ctr Oral Dis, Dept Oral Surg,Peoples Hosp 9,Sch Med, Shanghai 200001, Peoples R China
2.Univ Chinese Acad Sci, Hangzhou Stomatol Hosp, Hangzhou 310002, Zhejiang, Peoples R China
3.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Anhui, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
5.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
6.Shanghai Res Inst Stomatol, Shanghai 200001, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Dan,Lin, Haiyan,Zhang, Guilong,et al. Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(37):31114-31123.
APA Wang, Dan.,Lin, Haiyan.,Zhang, Guilong.,Si, Yuanchun.,Yang, Hongyi.,...&Zou, Duohong.(2018).Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,10(37),31114-31123.
MLA Wang, Dan,et al."Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 10.37(2018):31114-31123.

入库方式： OAI收割

来源：合肥物质科学研究院

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