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Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae

文献类型：期刊论文

作者Chen, Lianguo2; Yu, Ke2; Huang, Changjiang3; Yu, Liqin2; Zhu, Bingqing1,4,5; Lam, Paul K. S.1,4,5; Lam, James C. W.1,4,5; Zhou, Bingsheng2
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
出版日期2012-09-04
卷号46期号:17页码:9727-9734
关键词BROMINATED FLAME RETARDANTS MATERNAL TRANSFER THYROID-HORMONE 2 NEURONAL DEVELOPMENT NEONATAL EXPOSURE CEREBRAL-CORTEX SOUTH CHINA PROTEIN GROWTH 2' 4 4' 5-PENTABROMODIPHENYL ETHER
ISSN号0013-936X
通讯作者Lam, JCW (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China.
中文摘要Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.
英文摘要Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
类目[WOS]Engineering, Environmental ; Environmental Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
关键词[WOS]BROMINATED FLAME RETARDANTS ; MATERNAL TRANSFER ; THYROID-HORMONE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; NEURONAL DEVELOPMENT ; NEONATAL EXPOSURE ; CEREBRAL-CORTEX ; SOUTH CHINA ; PROTEIN ; GROWTH
收录类别SCI
资助信息National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
语种英语
WOS记录号WOS:000308260700063
公开日期2013-01-09
源URL[http://ir.ihb.ac.cn/handle/342005/17248]  
专题水生生物研究所_水环境工程研究中心_期刊论文
作者单位1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Wenzhou Med Coll, Inst Watershed Sci & Environm Ecol, Wenzhou 325035, Peoples R China
4.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Lianguo,Yu, Ke,Huang, Changjiang,et al. Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(17):9727-9734.
APA Chen, Lianguo.,Yu, Ke.,Huang, Changjiang.,Yu, Liqin.,Zhu, Bingqing.,...&Zhou, Bingsheng.(2012).Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(17),9727-9734.
MLA Chen, Lianguo,et al."Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.17(2012):9727-9734.

入库方式： OAI收割

来源：水生生物研究所

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