中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Molecular regulation of interferon antiviral response in fish (Review)

文献类型:期刊论文

作者Zhang, Yi-Bing ; Gui, Jian-Fang
刊名DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
出版日期2012
卷号38期号:2页码:193-202
关键词Fish IFN antiviral response Jak-Stat signaling pathway TLR pathway RLR pathway Auto-regulation Molecular regulation
ISSN号0145-305X
通讯作者Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
中文摘要Interferon (IFN) response is the first line of host defense against virus infection. The recent years have witnessed tremendous progress in understanding of fish IFN antiviral response. Varied number of IFN genes has been identified in different fish species but obviously, they do not show a one-to-one orthologous relationship with mammalian IFN homologs. These genes are divided into two groups with different abilities to induce downstream gene expression through binding to different receptor complexes. Consistently, some fish IFN-stimulated genes such as Mx and PKR have been confirmed for their antiviral effects. In this review, we focus on how fish cells respond to IFNs and how fish IFNs are triggered through TLR pathway and RLR pathway. We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
收录类别SCI
资助信息973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31172435]; Autonomous Project of State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ24]
语种英语
公开日期2013-01-09
源URL[http://ir.ihb.ac.cn/handle/342005/17240]  
专题水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
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Zhang, Yi-Bing,Gui, Jian-Fang. Molecular regulation of interferon antiviral response in fish (Review)[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(2):193-202.
APA Zhang, Yi-Bing,&Gui, Jian-Fang.(2012).Molecular regulation of interferon antiviral response in fish (Review).DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,38(2),193-202.
MLA Zhang, Yi-Bing,et al."Molecular regulation of interferon antiviral response in fish (Review)".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38.2(2012):193-202.

入库方式: OAI收割

来源:水生生物研究所

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