中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 天津工业生物技术研究所
  3. 结构生物信息学和整合系统生物学实验室 宋江宁
  4. 期刊论文
Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis

文献类型：期刊论文

作者Zhu, Yan1,2; Song, Jiangning3,4; Xu, Zixiang3; Sun, Jibin3; Zhang, Yanping; Li, Yin1; Ma, Yanhe1
刊名BIOTECHNOLOGY AND BIOENGINEERING
出版日期2013-03-01
卷号110期号:3页码:914-923
关键词flux balance analysis constraint-based metabolic model maximum entropy production principle energy loop law
英文摘要Flux balance analysis (FBA) has been widely used in calculating steady-state flux distributions that provide important information for metabolic engineering. Several thermodynamics-based methods, for example, quantitative assignment of reaction directionality and energy balance analysis have been developed to improve the prediction accuracy of FBA. However, these methods can only generate a thermodynamically feasible range, rather than the most thermodynamically favorable solution. We therefore developed a novel optimization method termed as thermodynamic optimum searching (TOS) to calculate the thermodynamically optimal solution, based on the second law of thermodynamics, the minimum magnitude of the Gibbs free energy change and the maximum entropy production principle (MEPP). Then, TOS was applied to five physiological conditions of Escherichia coli to evaluate its effectiveness. The resulting prediction accuracy was found significantly improved (10.748.5%) by comparing with the 13C-fluxome data, indicating that TOS can be considered an advanced calculation and prediction tool in metabolic engineering. Biotechnol. Bioeng. 2013; 110: 914923. (c) 2012 Wiley Periodicals, Inc.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]MAXIMUM-ENTROPY PRODUCTION ; PYRUVATE FORMATE-LYASE ; ESCHERICHIA-COLI K-12 ; COMPLEX METABOLIC NETWORKS ; HIGH-THROUGHPUT ; MODELS ; RECONSTRUCTION ; PERTURBATIONS ; INACTIVATION ; CONSTRAINTS
收录类别SCI
语种英语
WOS记录号WOS:000313806400025
公开日期2013-01-16
源URL[http://124.16.173.210/handle/312001/303]  
专题天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室 宋江宁_期刊论文
作者单位1.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China
4.Monash Univ, Fac Med, Dept Biochem & Mol Biol, Melbourne, Vic 3004, Australia
推荐引用方式
GB/T 7714		 Zhu, Yan,Song, Jiangning,Xu, Zixiang,et al. Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis[J]. BIOTECHNOLOGY AND BIOENGINEERING,2013,110(3):914-923.
APA Zhu, Yan.,Song, Jiangning.,Xu, Zixiang.,Sun, Jibin.,Zhang, Yanping.,...&Ma, Yanhe.(2013).Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis.BIOTECHNOLOGY AND BIOENGINEERING,110(3),914-923.
MLA Zhu, Yan,et al."Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis".BIOTECHNOLOGY AND BIOENGINEERING 110.3(2013):914-923.

入库方式： OAI收割

来源：天津工业生物技术研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。