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Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation

文献类型：期刊论文

作者Hong, Shuai2; Hu, Supei1; Kang, Zhengyang4; Liu, Zhiguo3; Yang, Weibin3; Zhang, Yongzhi3; Yang, Dengfeng3; Ruan, Wenhui3; Yu, Guoyong3; Sun, Liang2
刊名JOURNAL OF CELLULAR PHYSIOLOGY
出版日期2019-09-04
页码13
关键词ceRNA feedback loops lncRNA osteoblast differentiation
ISSN号0021-9541
DOI10.1002/jcp.29132
英文摘要Adult human mesenchymal stem cells have the potential to differentiate into osteoblast, which plays crucial roles in bone regeneration and repair. Some transcriptional factors (TFs), such as BMP-2 and RUNX2, have been demonstrated to control the differentiation processes. It is important to discover more key regulators in osteoblast differentiation. Recently, some studies found long noncoding RNAs (lncRNAs) participating in osteoblast differentiation, such as MALAT1, DANCR, and ANCR. In this study, we performed a network-based computational analysis to investigate the lncRNA-messenger RNA (mRNA) crosstalks via integrating microRNA (miRNA)-RNA interactions, gene coexpression, and protein-protein interactions. First, multiple topology analyses were performed to osteoblast-differentiation-related lncRNA-mRNA network (ODLMN). Several lncRNAs with central topology structures were identified as key regulators. Results showed that these lncRNAs participated in osteoblast differentiation via phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase, and Ras signals. Previous studies have demonstrated that lncRNAs exert functions by involving in close modules. Second, after performing module searching in ODLMN, two functional modules were identified, which played crucial roles through involving in PI3K/protein kinase B, cyclic adenosine 3MODIFIER LETTER PRIME,5MODIFIER LETTER PRIME-monophosphate, and hypoxia-inducible factor 1 pathways. Third, a subset of core lncRNA-TF crosstalks that might form feedback loops to control the biological processes in osteoblast differentiation was identified. These core lncRNA-TF feedback loops showed more TF binding affinity than other lncRNAs. All these results can help us to uncover the molecular mechanism and provide new targets for bone regeneration and repair.
资助项目Medical Scientific Research Foundation of Zhejiang Province, China[2015KYB342]
WOS研究方向Cell Biology ; Physiology
语种英语
WOS记录号WOS:000485028500001
出版者WILEY
源URL[http://119.78.100.204/handle/2XEOYT63/4693]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Yu, Guoyong; Sun, Liang; Chen, Liang
作者单位1.Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, 6 Kexueyuan South Rd Zhongguancun, Beijing 100190, Peoples R China
3.Hanzhong Cent Hosp, Dept Osteoarthrit Trauma, Hanzhong, Peoples R China
4.Second Peoples Hosp Panyu, Dept Orthoped, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Hong, Shuai,Hu, Supei,Kang, Zhengyang,et al. Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2019:13.
APA Hong, Shuai.,Hu, Supei.,Kang, Zhengyang.,Liu, Zhiguo.,Yang, Weibin.,...&Chen, Liang.(2019).Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation.JOURNAL OF CELLULAR PHYSIOLOGY,13.
MLA Hong, Shuai,et al."Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation".JOURNAL OF CELLULAR PHYSIOLOGY (2019):13.

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来源：计算技术研究所

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