The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma
文献类型：期刊论文
| 作者 | Zhao, Shuangtao2,3; Fang, Shuangsang1; Liu, Yanhua5,6,7; Li, Xixi4,5; Liao, Shengyou1; Chen, Jinwen1; Liu, Jingjia1; Zhao, Lianhe1; Li, Hui1; Zhou, Wei5,6,7 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017-05-23 |
| 卷号 | 8期号:21页码:34374-34386 |
| 关键词 | diffuse large B-cell lymphoma long non-coding RNA NONHSAG026900 prognosis biomarker |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.16163 |
| 英文摘要 | Long non-coding RNAs are known to be involved in cancer progression, but their biological functions and prognostic values are still largely unexplored in diffuse large B-cell lymphoma. In this study, long non-coding RNAs expression was characterized in 1,403 samples including normal and diffuse large B-cell lymphoma by repurposing 7 microarray datasets. Compared with any stage of normal B cells, NONHSAG026900 expression was significantly decreased in tumor samples. And in germinal center B-cell subtype, the significantly higher expression of NONHSAG026900 indicated it was a favorable prognosis biomarker. Then the prognostic power of NONHSAG026900 was validated with another independent dataset and NONHSAG026900 improved the predictive power of International Prognostic Index as an independent factor. Moreover, functional prediction and validation demonstrated that NONHSAG026900 could inhibit cell cycle activity to restrain tumor proliferation. These findings identified NONHSAG026900 as a novel prognostic biomarker and offered a new therapeutic target for diffuse large B-cell lymphoma patients. |
| 资助项目 | National Natural Science Foundation of China[31371320] ; National Natural Science Foundation of China[31401119] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31501066] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000402051700035 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/7241]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Xiang, Rong; Wang, Luhua; Zhao, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 2.Chinese Acad Med Sci, Beijing, Peoples R China 3.Peking Union Med Coll, Dept Radiat Oncol, Natl Canc Ctr, Canc Hosp, Beijing, Peoples R China 4.Nankai Univ, Dept Pathol, Tianjin, Peoples R China 5.Nankai Univ, Sch Med, Tianjin, Peoples R China 6.Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin, Peoples R China 7.Tianjin Key Lab Tumor Microenvironm & Neurovasc R, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Shuangtao,Fang, Shuangsang,Liu, Yanhua,et al. The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma[J]. ONCOTARGET,2017,8(21):34374-34386. |
| APA | Zhao, Shuangtao.,Fang, Shuangsang.,Liu, Yanhua.,Li, Xixi.,Liao, Shengyou.,...&Zhao, Yi.(2017).The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma.ONCOTARGET,8(21),34374-34386. |
| MLA | Zhao, Shuangtao,et al."The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma".ONCOTARGET 8.21(2017):34374-34386. |
入库方式： OAI收割
来源：计算技术研究所
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