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A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

文献类型：期刊论文

作者Wu, Liangcai1,3,4; Xu, Qianqian2,4; Zhang, Haohai3,4; Li, Ming1; Zhu, Chengpei3,4; Jiang, Minjie1; Sang, Xinting3,4; Zhao, Yi1,3,4; Sun, Qiang2,4; Zhao, Haitao3,4
刊名SCIENTIFIC REPORTS
出版日期2016-08-19
卷号6页码:8
ISSN号2045-2322
DOI10.1038/srep31716
英文摘要Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding-non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan-Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored.
资助项目International Science and Technology Cooperation Projects[2015DFA30650] ; International Science and Technology Cooperation Projects[2010DFB33720] ; Capital Special Research Project for Health Development[2014-2-4012] ; Capital research project for the characteristics clinical application[Z151100004015170] ; Program for New Century Excellent Talents in University[NCET-11-0288]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000381614400001
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.204/handle/2XEOYT63/8060]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zhao, Yi; Sun, Qiang; Zhao, Haitao
作者单位1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing, Peoples R China
2.Chinese Acad Med Sci, Dept Breast Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China
3.Chinese Acad Med Sci, Dept Liver Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China
4.Peking Union Med Coll, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Liangcai,Xu, Qianqian,Zhang, Haohai,et al. A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling[J]. SCIENTIFIC REPORTS,2016,6:8.
APA Wu, Liangcai.,Xu, Qianqian.,Zhang, Haohai.,Li, Ming.,Zhu, Chengpei.,...&Zhao, Haitao.(2016).A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling.SCIENTIFIC REPORTS,6,8.
MLA Wu, Liangcai,et al."A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling".SCIENTIFIC REPORTS 6(2016):8.

入库方式： OAI收割

来源：计算技术研究所

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