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ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography

文献类型：期刊论文

作者Deng, Yuchen1,4; Chen, Yu2,4; Zhang, Yan1; Wang, Shengliu1,4; Zhang, Fa2; Sun, Fei1,3,4
刊名JOURNAL OF STRUCTURAL BIOLOGY
出版日期2016-07-01
卷号195期号:1页码:100-112
关键词Compressed sensing Electron tomography Missing wedge NUFFT Sub-tomogram averaging
ISSN号1047-8477
DOI10.1016/j.jsb.2016.04.004
英文摘要Electron tomography (ET) plays an important role in revealing biological structures, ranging from macro molecular to subcellular scale. Due to limited tilt angles, ET reconstruction always suffers from the 'missing wedge' artifacts, thus severely weakens the further biological interpretation. In this work, we developed an algorithm called Iterative Compressed-sensing Optimized Non-uniform fast Fourier transform reconstruction (ICON) based on the theory of compressed-sensing and the assumption of sparsity of biological specimens. ICON can significantly restore the missing information in comparison with other reconstruction algorithms. More importantly, we used the leave-one-out method to verify the validity of restored information for both simulated and experimental data. The significant improvement in sub-tomogram averaging by ICON indicates its great potential in the future application of high resolution structural determination of macromolecules in situ. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
资助项目Strategic Priority Research Program of Chinese Academy of Sciences[XDB08030202] ; National Basic Research Program (973 Program) of Ministry of Science and Technology of China[2014CB910700] ; National Natural Science Foundation of China[61232001] ; National Natural Science Foundation of China[61502455] ; National Natural Science Foundation of China[61472397] ; National Natural Science Foundation of China[31470037] ; National Natural Science Foundation of China[31100617]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
语种英语
WOS记录号WOS:000377735300011
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.204/handle/2XEOYT63/8360]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zhang, Fa; Sun, Fei
作者单位1.Chinese Acad Sci, Inst Biophys, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Deng, Yuchen,Chen, Yu,Zhang, Yan,et al. ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography[J]. JOURNAL OF STRUCTURAL BIOLOGY,2016,195(1):100-112.
APA Deng, Yuchen,Chen, Yu,Zhang, Yan,Wang, Shengliu,Zhang, Fa,&Sun, Fei.(2016).ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography.JOURNAL OF STRUCTURAL BIOLOGY,195(1),100-112.
MLA Deng, Yuchen,et al."ICON: 3D reconstruction with 'missing-information' restoration in biological electron tomography".JOURNAL OF STRUCTURAL BIOLOGY 195.1(2016):100-112.

入库方式： OAI收割

来源：计算技术研究所

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