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Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy

文献类型：期刊论文

作者Luo, Zhenyu1,4; Zheng, Mingbin1,2; Zhao, Pengfei1,4; Chen, Ze1; Siu, Fungming3; Gong, Ping1; Gao, Guanhui1; Sheng, Zonghai1; Zheng, Cuifang1; Ma, Yifan1
刊名SCIENTIFIC REPORTS
出版日期2016-03-18
卷号6页码:11
ISSN号2045-2322
DOI10.1038/srep23393
英文摘要Photodynamic therapy has been increasingly applied in clinical cancer treatments. However, native hypoxic tumoural microenvironment and lacking oxygen supply are the major barriers hindering photodynamic reactions. To solve this problem, we have developed biomimetic artificial red cells by loading complexes of oxygen-carrier (hemoglobin) and photosensitizer (indocyanine green) for boosted photodynamic strategy. Such nanosystem provides a coupling structure with stable self-oxygen supply and acting as an ideal fluorescent/photoacoustic imaging probe, dynamically monitoring the nanoparticle biodistribution and the treatment of PDT. Upon exposure to near-infrared laser, the remote-triggered photosensitizer generates massive cytotoxic reactive oxygen species (ROS) with sufficient oxygen supply. Importantly, hemoglobin is simultaneously oxidized into the more active and resident ferryl-hemoglobin leading to persistent cytotoxicity. ROS and ferryl-hemoglobin synergistically trigger the oxidative damage of xenograft tumour resulting in complete suppression. The artificial red cells with self-monitoring and boosted photodynamic efficacy could serve as a versatile theranostic platform.
资助项目National Natural Science Foundation of China[31571013] ; National Natural Science Foundation of China[21203237] ; National Natural Science Foundation of China[81401520] ; National Natural Science Foundation of China[81171446] ; Instrument Developing Project of the CAS[YZ201439] ; Key International S&T Cooperation Project[2015DFH50230] ; Guangdong Science and Technology Key Project[2012A061400013] ; Guangdong Science and Technology Key Project[2012B090400043] ; Shenzhen Science and Technology Program[KQCX20140521115045447] ; Shenzhen Science and Technology Program[GJHS20140610152828690] ; Shenzhen Bioactive Materials Engineering Lab for Medicine[[2013]154] ; China Postdoctoral Science Foundation Funded Project[2015M572387] ; Dongguan project on Social science and Technology Development[2015108101019] ; Guangdong medical university fund[2XB14015]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000372482900001
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.204/handle/2XEOYT63/8707]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zheng, Mingbin; Ma, Yifan; Cai, Lintao
作者单位1.Chinese Acad Sci, SIAT, Guangdong Key Lab Nanomed, CAS Key Lab Hlth Informat,Inst Biomed & Biotechno, Shenzhen 518055, Peoples R China
2.Guangdong Med Univ, Dept Chem, Dongguan 523808, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Adv Comp & Digital Engn, Ctr High Performance Comp, Shenzhen 518055, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Zhenyu,Zheng, Mingbin,Zhao, Pengfei,et al. Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2016,6:11.
APA Luo, Zhenyu.,Zheng, Mingbin.,Zhao, Pengfei.,Chen, Ze.,Siu, Fungming.,...&Cai, Lintao.(2016).Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy.SCIENTIFIC REPORTS,6,11.
MLA Luo, Zhenyu,et al."Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy".SCIENTIFIC REPORTS 6(2016):11.

入库方式： OAI收割

来源：计算技术研究所

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