Evolutionary annotation of conserved long non-coding RNAs in major mammalian species
文献类型：期刊论文
| 作者 | Bu DeChao1,2; Luo HaiTao1,2; Jiao Fei3; Fang ShuangSang1,2; Tan ChengFu1,2; Liu ZhiYong1; Zhao Yi1 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 58期号:8页码:787-798 |
| 关键词 | lncRNA conservation evolution |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-015-4881-9 |
| 英文摘要 | Mammalian genomes contain tens of thousands of long non-coding RNAs (lncRNAs) that have been implicated in diverse biological processes. However, the lncRNA transcriptomes of most mammalian species have not been established, limiting the evolutionary annotation of these novel transcripts. Based on RNA sequencing data from six tissues of nine species, we built comprehensive lncRNA catalogs (4,142-42,558 lncRNAs) covering the major mammalian species. Compared to protein- coding RNAs, expression of lncRNAs exhibits striking lineage specificity. Notably, although 30%-99% human lncRNAs are conserved across different species on DNA locus level, only 20%-27% of these conserved lncRNA loci are detected to transcription, which represents a stark contrast to the proportion of conserved protein-coding genes (48%-80%). This finding provides a valuable resource for experimental scientists to study the mechanisms of lncRNAs. Moreover, we constructed lncRNA expression phylogenetic trees across nine mammals and demonstrated that lncRNA expression profiles can reliably determine phylogenic placement in a manner similar to their coding counterparts. Our data also reveal that the evolutionary rate of lncRNA expression varies among tissues and is significantly higher than those for protein-coding genes. To streamline the processes of browsing lncRNAs and detecting their evolutionary statuses, we integrate all the data produced in this study into a database named PhyloNONCODE (http://www.bioinfo.org/phyloNoncode). Our work starts to place mammalian lncRNAs in an evolutionary context and represent a rich resource for comparative and functional analyses of this critical layer of genome. |
| 资助项目 | National Natural Science Foundation of China[91229120] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000359146800008 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/9508]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Zhao Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Binzhou Med Coll, Dept Biochem & Mol Biol, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bu DeChao,Luo HaiTao,Jiao Fei,et al. Evolutionary annotation of conserved long non-coding RNAs in major mammalian species[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(8):787-798. |
| APA | Bu DeChao.,Luo HaiTao.,Jiao Fei.,Fang ShuangSang.,Tan ChengFu.,...&Zhao Yi.(2015).Evolutionary annotation of conserved long non-coding RNAs in major mammalian species.SCIENCE CHINA-LIFE SCIENCES,58(8),787-798. |
| MLA | Bu DeChao,et al."Evolutionary annotation of conserved long non-coding RNAs in major mammalian species".SCIENCE CHINA-LIFE SCIENCES 58.8(2015):787-798. |
入库方式： OAI收割
来源：计算技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。