Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics
文献类型：期刊论文
| 作者 | Zhang, ZH; Zhang, Y; Shi, BC; Deng, W; Zhao, Y; Chen, RS |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2004-05-01 |
| 卷号 | 49期号:10页码:1051-1054 |
| 关键词 | 5 '/3 ' UTRs mRNA trans-splicing chromosomal translocations chimeric |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/03wc0611 |
| 英文摘要 | The 5'/3'UTRs of mRNA are crucial in translational regulation, and several serious diseases are believed to be associated with abnormal splicing of these parts of the mRNA sequence. In this work a novel method which uses sequence alignment database searching for detecting chimeric 5'3' UTRs with cross-chromosomal splicing is reported. Eight highly credible instances of cross-chromosomal splicing have been found using this method, representing additional confirmation of the existence of cross-chromosomal splicing events provided by bioinformatics tools. Since no conserved motif has been found in any of the eight instances, and at the same time current prediction algorithms produce only trivial secondary structures at the "splicing sites", it is not possible to identify any specific signal leading to the splicing. |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000223146800013 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/9804]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Chen, RS |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, ZH,Zhang, Y,Shi, BC,et al. Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics[J]. CHINESE SCIENCE BULLETIN,2004,49(10):1051-1054. |
| APA | Zhang, ZH,Zhang, Y,Shi, BC,Deng, W,Zhao, Y,&Chen, RS.(2004).Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics.CHINESE SCIENCE BULLETIN,49(10),1051-1054. |
| MLA | Zhang, ZH,et al."Detecting chimeric 5 '/3 ' UTRs with cross-chromosomal splicing by bioinformatics".CHINESE SCIENCE BULLETIN 49.10(2004):1051-1054. |
入库方式： OAI收割
来源：计算技术研究所
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