A cross-species alignment tool (CAT)
文献类型：期刊论文
| 作者 | Li, Heng; Guan, Liang; Liu, Tao; Guo, Yiran; Zheng, Wei-Mou; Wong, Gane Ka-Shu; Wang, Jun |
| 刊名 | BMC BIOINFORMATICS
 |
| 出版日期 | 2007-09-19 |
| 卷号 | 8页码:8 |
| ISSN号 | 1471-2105 |
| DOI | 10.1186/1471-2105-8-349 |
| 英文摘要 | Background: The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more sensitive methods which are usually applied in aligning inter-species sequences. Results: Here we present a new algorithm called CAT ( for Cross-species Alignment Tool). It is designed to align mRNA sequences to mammalian-sized genomes. CAT is implemented using C scripts and is freely available on the web at http://xat.sourceforge.net/. Conclusions: Examined from different angles, CAT outperforms other extant alignment tools. Tested against all available mouse-human and zebrafish-human orthologs, we demonstrate that CAT combines the specificity and speed of the best intra-species algorithms, like BLAT and sim4, with the sensitivity of the best inter-species tools, like GeneWise. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Mathematical & Computational Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000251410100001 |
| 出版者 | BIOMED CENTRAL LTD |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/11052]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Zheng, Wei-Mou |
| 作者单位 | 1.Univ Aarhus, Inst Human Genet, DK-8000 Aarhus, Denmark 2.Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China 3.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310008, Peoples R China 4.Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 6.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 7.Univ Washington, Dept Med, UW Genome Ctr, Seattle, WA 98195 USA 8.Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark |
| 推荐引用方式 GB/T 7714 | Li, Heng,Guan, Liang,Liu, Tao,et al. A cross-species alignment tool (CAT)[J]. BMC BIOINFORMATICS,2007,8:8. |
| APA | Li, Heng.,Guan, Liang.,Liu, Tao.,Guo, Yiran.,Zheng, Wei-Mou.,...&Wang, Jun.(2007).A cross-species alignment tool (CAT).BMC BIOINFORMATICS,8,8. |
| MLA | Li, Heng,et al."A cross-species alignment tool (CAT)".BMC BIOINFORMATICS 8(2007):8. |
入库方式： OAI收割
来源：计算技术研究所
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