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GC content variability of eubacteria is governed by the pol III alpha subunit

文献类型：期刊论文

作者Zhao, Xiaoqian; Zhang, Zhang; Yan, Jiangwei; Yu, Jun
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2007-04-27
卷号356期号:1页码:20-25
关键词genomic GC content DNA polymerase III alpha subunit dnaE polC
ISSN号0006-291X
DOI10.1016/j.bbrc.2007.02.109
英文摘要Eubacterial genomes have highly variable GC content (0.17-0.75) and the primary mechanism of such variability remains unknown. The place to look for is what actually catalyzes the synthesis of DNA, where DNA polymerase III is at the center stage, particularly one of its 10 subunits-the alpha subunit. According to the dimeric combination of a subunits, GC contents of eubacterial genomes were partitioned into three groups with distinct GC content variation spectra: dnaE1 (full-spectrum), dnaE2/dnaE1 (high-GC), and polC/dnaE3 (low-GC). Therefore, genomic GC content variability is believed to be governed primarily by the alpha subunit grouping of DNA polymerase III; it is of essence in genome composition analysis to take full account of such a grouping principle. Since horizontal gene transfer is very frequent among bacterial genomes, exceptions of the grouping scheme, a few percents of the total, are readily identifiable and should be excluded from in-depth analyses on nucleotide compositions. (c) 2007 Elsevier Inc. All rights reserved.
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000245419300004
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.204/handle/2XEOYT63/11058]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Yu, Jun
作者单位1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 101300, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Xiaoqian,Zhang, Zhang,Yan, Jiangwei,et al. GC content variability of eubacteria is governed by the pol III alpha subunit[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,356(1):20-25.
APA Zhao, Xiaoqian,Zhang, Zhang,Yan, Jiangwei,&Yu, Jun.(2007).GC content variability of eubacteria is governed by the pol III alpha subunit.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,356(1),20-25.
MLA Zhao, Xiaoqian,et al."GC content variability of eubacteria is governed by the pol III alpha subunit".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356.1(2007):20-25.

入库方式： OAI收割

来源：计算技术研究所

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