MicroRNA-encoding long non-coding RNAs
文献类型：期刊论文
| 作者 | He, Shunmin2,3,4; Su, Hua2,3,4; Liu, Changning1,4; Skogerbo, Geir2,3; He, Housheng2,3; He, Dandan2,3; Zhu, Xiaopeng2,3; Liu, Tao2,3; Zhao, Yi1; Chen, Runsheng2,3 |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2008-05-21 |
| 卷号 | 9页码:11 |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/1471-2164-9-236 |
| 英文摘要 | Background: Recent analysis of the mouse transcriptional data has revealed the existence of similar to 34,000 messenger-like non-coding RNAs (ml-ncRNAs). Whereas the functional properties of these ml-ncRNAs are beginning to be unravelled, no functional information is available for the large majority of these transcripts. Results: A few ml-ncRNA have been shown to have genomic loci that overlap with microRNA loci, leading us to suspect that a fraction of ml-ncRNA may encode microRNAs. We therefore developed an algorithm (PriMir) for specifically detecting potential microRNA-encoding transcripts in the entire set of 34,030 mouse full-length ml-ncRNAs. In combination with mouse-rat sequence conservation, this algorithm detected 97 ( 80 of them were novel) strong miRNA-encoding candidates, and for 52 of these we obtained experimental evidence for the existence of their corresponding mature microRNA by microarray and stem-loop RT-PCR. Sequence analysis of the microRNA-encoding RNAs revealed an internal motif, whose presence correlates strongly (R(2) = 0.9, P-value = 2.2 x 10(-16)) with the occurrence of stem-loops with characteristics of known pre-miRNAs, indicating the presence of a larger number microRNA-encoding RNAs (from 300 up to 800) in the ml-ncRNAs population. Conclusion: Our work highlights a unique group of ml-ncRNAs and offers clues to their functions. |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000256400500001 |
| 出版者 | BIOMED CENTRAL LTD |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/11147]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Chen, Runsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Bioinformat Res Grp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Shunmin,Su, Hua,Liu, Changning,et al. MicroRNA-encoding long non-coding RNAs[J]. BMC GENOMICS,2008,9:11. |
| APA | He, Shunmin.,Su, Hua.,Liu, Changning.,Skogerbo, Geir.,He, Housheng.,...&Chen, Runsheng.(2008).MicroRNA-encoding long non-coding RNAs.BMC GENOMICS,9,11. |
| MLA | He, Shunmin,et al."MicroRNA-encoding long non-coding RNAs".BMC GENOMICS 9(2008):11. |
入库方式： OAI收割
来源：计算技术研究所
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