中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae

文献类型:期刊论文

作者Chen Lan1,2; Cai Lun1,2; Geir Skogerb3; Chen Run-Sheng1,3
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2008
卷号35期号:1页码:35-42
关键词transcriptional regulatory network collaboration network anomaly
ISSN号1000-3282
英文摘要Collaboration networks have proven informative when used to describe various kinds of human relationships. Similar strategy could be used in the transcriptional regulatory network. A collaboration network of target genes (TGs) was constructed based on common transcription factors (TFs), and similarly, a smaller network of transcription factors was constructed based on their common target genes. After clustering the target gene collaboration networks, genes in the same cluster were often enriched for one or more GO terms. The results also showed that genes with specific GO terms tend to share similar regulatory mechanisms. It indicates that in a collaboration network approach the relatively simple "regulatory mechanism" measure used here was able to extract considerable biologically relevant information. Moreover, a definition of anomaly used before in a bipartite graph analysis method was applied into the collaboration networks analysis. And the correlation between the anomalies and the essential genes was discovered. In a conclusion, a collaboration network approach may be a valuable supplement to other analyses of transcriptional networks.
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000254046500005
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
源URL[http://119.78.100.204/handle/2XEOYT63/11379]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Chen Run-Sheng
作者单位1.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Bioinformat Lab, Inst Biophys, Beijing 1000101, Peoples R China
推荐引用方式
GB/T 7714
Chen Lan,Cai Lun,Geir Skogerb,et al. Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2008,35(1):35-42.
APA Chen Lan,Cai Lun,Geir Skogerb,&Chen Run-Sheng.(2008).Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,35(1),35-42.
MLA Chen Lan,et al."Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35.1(2008):35-42.

入库方式: OAI收割

来源:计算技术研究所

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