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Clustered microRNAs' coordination in regulating protein-protein interaction network

文献类型：期刊论文

作者Yuan, Xiongying1,2; Liu, Changning2; Yang, Pengcheng1,2; He, Shunmin1,2; Liao, Qi2,3; Kang, Shuli2; Zhao, Yi2
刊名BMC SYSTEMS BIOLOGY
出版日期2009-06-26
卷号3页码:10
ISSN号1752-0509
DOI10.1186/1752-0509-3-65
英文摘要Background: MicroRNAs (miRNAs), a growing class of small RNAs with crucial regulatory roles at the post-transcriptional level, are usually found to be clustered on chromosomes. However, with the exception of a few individual cases, so far little is known about the functional consequence of this conserved clustering of miRNA loci. In animal genomes such clusters often contain non-homologous miRNA genes. One hypothesis to explain this heterogeneity suggests that clustered miRNAs are functionally related by virtue of co-targeting downstream pathways. Results: Integrating of miRNA cluster information with protein protein interaction (PPI) network data, our research supports the hypothesis of the functional coordination of clustered miRNAs and links it to the topological features of miRNAs' targets in PPI network. Specifically, our results demonstrate that clustered miRNAs jointly regulate proteins in close proximity of the PPI network. The possibility that two proteins yield to this coordinated regulation is negatively correlated with their distance in PPI network. Guided by the knowledge of this preference, we found several network communities enriched with target genes of miRNA clusters. In addition, our results demonstrate that the variance of this propensity can also partly be explained by protein's connectivity and miRNA's conservation. Conclusion: In summary, this work supports the hypothesis of intra-cluster coordination and investigates the extent of this coordination.
资助项目National Sciences Foundation of China[30570393] ; National Sciences Foundation of China[30600729]
WOS研究方向Mathematical & Computational Biology
语种英语
WOS记录号WOS:000268816600001
出版者BIOMED CENTRAL LTD
源URL[http://119.78.100.204/handle/2XEOYT63/11629]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zhao, Yi
作者单位1.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Ctr Adv Comp Res, Bioinformat Grp, Beijing, Peoples R China
3.Sun Yat Sen Univ, Dept Parasitol, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Xiongying,Liu, Changning,Yang, Pengcheng,et al. Clustered microRNAs' coordination in regulating protein-protein interaction network[J]. BMC SYSTEMS BIOLOGY,2009,3:10.
APA Yuan, Xiongying.,Liu, Changning.,Yang, Pengcheng.,He, Shunmin.,Liao, Qi.,...&Zhao, Yi.(2009).Clustered microRNAs' coordination in regulating protein-protein interaction network.BMC SYSTEMS BIOLOGY,3,10.
MLA Yuan, Xiongying,et al."Clustered microRNAs' coordination in regulating protein-protein interaction network".BMC SYSTEMS BIOLOGY 3(2009):10.

入库方式： OAI收割

来源：计算技术研究所

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