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ECD/ETD-based Tandem Mass Spectrometry in Proteomics

文献类型：期刊论文

作者Sun Rui-Xiang2; Dong Meng-Qiu1; Chi Hao2; Yang Bing1; Xiu Li-Yun2; Wang Le-Heng2; Fu Yan2; He Si-Min2
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2010
卷号37期号:1页码:94-102
关键词electron capture dissociation electron transfer dissociation collision induced dissociation tandem mass spectrometry computational proteomics
ISSN号1000-3282
DOI10.3724/SP.J.1206.2009.00352
英文摘要Proteomics has propelled the rapid development of mass spectrometry (MS) in the past ten years. Conversely, the advancement of MS has greatly expanded the horizon of proteomics research by allowing it to address questions never touched before. Standing out among the recent technological innovations in MS are electron capture dissociation (ECD) and electron transfer dissociation (ETD). These electron-based fragmentation methods have shown a great potential for analysis of proteolytic peptides as well as intact proteins. A promising future lies ahead for ECD- or ETD-based techniques in proteomics research, especially in studies of protein post-translational modifications and top-down analysis of intact proteins. The mechanism, instrumentation and application of ECD/ETD, along with the spectral characteristics and data analysis of peptides ECD/ETD spectra were reviewed. The current issues in ECD/ETD applications or method development, the challenges for software development, and the outlook of these techniques in future research were also discussed.
资助项目Hi-Tech Research and Development Program of China[2008AA02Z309] ; Hi-Tech Research and Development Program of China[2007AA02Z315] ; Hi-Tech Research and Development Program of China[2007AA02Z1A7] ; National Basic Research Program of China[2010CB912701] ; The Chinese Academy of Sciences Knowledge Innovative Project[KGGX1-YW-13]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000273981400014
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
源URL[http://119.78.100.204/handle/2XEOYT63/12312]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Sun Rui-Xiang
作者单位1.Natl Inst Biol Sci, Beijing 102206, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Sun Rui-Xiang,Dong Meng-Qiu,Chi Hao,et al. ECD/ETD-based Tandem Mass Spectrometry in Proteomics[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2010,37(1):94-102.
APA Sun Rui-Xiang.,Dong Meng-Qiu.,Chi Hao.,Yang Bing.,Xiu Li-Yun.,...&He Si-Min.(2010).ECD/ETD-based Tandem Mass Spectrometry in Proteomics.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,37(1),94-102.
MLA Sun Rui-Xiang,et al."ECD/ETD-based Tandem Mass Spectrometry in Proteomics".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37.1(2010):94-102.

入库方式： OAI收割

来源：计算技术研究所

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