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ncFANs: a web server for functional annotation of long non-coding RNAs

文献类型：期刊论文

作者Liao, Qi2,3,4; Xiao, Hui2; Bu, Dechao2,5; Xie, Chaoyong2; Miao, Ruoyu1,6; Luo, Haitao2; Zhao, Guoguang2,5; Yu, Kuntao2,5; Zhao, Haitao1,6; Skogerbo, Geir7,8
刊名NUCLEIC ACIDS RESEARCH
出版日期2011-07-01
卷号39页码:W118-W124
ISSN号0305-1048
DOI10.1093/nar/gkr432
英文摘要Recent interest in the non-coding transcriptome has resulted in the identification of large numbers of long non-coding RNAs (lncRNAs) in mammalian genomes, most of which have not been functionally characterized. Computational exploration of the potential functions of these lncRNAs will therefore facilitate further work in this field of research. We have developed a practical and user-friendly web interface called ncFANs (non-coding RNA Function ANnotation server), which is the first web service for functional annotation of human and mouse lncRNAs. On the basis of the re-annotated Affymetrix microarray data, ncFANs provides two alternative strategies for lncRNA functional annotation: one utilizing three aspects of a coding-non-coding gene co-expression (CNC) network, the other identifying condition-related differentially expressed lncRNAs. ncFANs introduces a highly efficient way of re-using the abundant pre-existing microarray data. The present version of ncFANs includes re-annotated CDF files for 10 human and mouse Affymetrix microarrays, and the server will be continuously updated with more re-annotated microarray platforms and lncRNA data. ncFANs is freely accessible at http://www.ebiomed.org/ncFANs/ or http://www.noncode.org/ncFANs/.
资助项目Chinese Academy of Sciences[KSCX2-EW-R-01] ; Beijing Institutes of Life Science ; National Natural Science Foundation of China[31071137] ; National Natural Science Foundation of China[31000586] ; National Natural Science Foundation of China[30970623] ; International Science and Technology Cooperation Projects[2010DFA31840] ; International Science and Technology Cooperation Projects[2010DFB33720]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000292325300020
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.204/handle/2XEOYT63/12597]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zhao, Yi
作者单位1.PUMC, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Bioinformat Res Grp, Key Lab Intelligent Informat Proc, Adv Comp Res Lab,Inst Comp Technol, Beijing, Peoples R China
3.Sun Yat Sen Univ, Dept Parasitol, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510275, Guangdong, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
6.Chinese Acad Med Sci, Dept Liver Surg, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
7.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100080, Peoples R China
8.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Liao, Qi,Xiao, Hui,Bu, Dechao,et al. ncFANs: a web server for functional annotation of long non-coding RNAs[J]. NUCLEIC ACIDS RESEARCH,2011,39:W118-W124.
APA Liao, Qi.,Xiao, Hui.,Bu, Dechao.,Xie, Chaoyong.,Miao, Ruoyu.,...&Zhao, Yi.(2011).ncFANs: a web server for functional annotation of long non-coding RNAs.NUCLEIC ACIDS RESEARCH,39,W118-W124.
MLA Liao, Qi,et al."ncFANs: a web server for functional annotation of long non-coding RNAs".NUCLEIC ACIDS RESEARCH 39(2011):W118-W124.

入库方式： OAI收割

来源：计算技术研究所

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