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Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network
文献类型：期刊论文
| 作者 | Liao, Qi1,6,7; Liu, Changning6; Yuan, Xiongying2,6; Kang, Shuli6; Miao, Ruoyu3; Xiao, Hui6; Zhao, Guoguang2,6; Luo, Haitao6; Bu, Dechao2,6; Zhao, Haitao3 |
| 刊名 | NUCLEIC ACIDS RESEARCH
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 39期号:9页码:3864-3878 |
| ISSN号 | 0305-1048 |
| DOI | 10.1093/nar/gkq1348 |
| 英文摘要 | Although accumulating evidence has provided insight into the various functions of long-non-coding RNAs (lncRNAs), the exact functions of the majority of such transcripts are still unknown. Here, we report the first computational annotation of lncRNA functions based on public microarray expression profiles. A coding-non-coding gene co-expression (CNC) network was constructed from re-annotated Affymetrix Mouse Genome Array data. Probable functions for altogether 340 lncRNAs were predicted based on topological or other network characteristics, such as module sharing, association with network hubs and combinations of co-expression and genomic adjacency. The functions annotated to the lncRNAs mainly involve organ or tissue development (e.g. neuron, eye and muscle development), cellular transport (e.g. neuronal transport and sodium ion, acid or lipid transport) or metabolic processes (e.g. involving macromolecules, phosphocreatine and tyrosine). |
| 资助项目 | National High Technology Research and Development of China[2008AA02Z306] ; Chinese Academy of Sciences[KSCX2-EW-R-01] ; National Program on Key Basic Research Project[2010CB530004] ; National Natural Science Foundation of China[31071137] ; National Natural Science Foundation of China[30771888] ; National Natural Science Foundation of China[30972574] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000290589500037 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/12674]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Zhao, Yi |
| 作者单位 | 1.Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Peking Union Med Coll Hosp, Dept Liver Surg, CAMS & PUMC, Beijing, Peoples R China 4.Chinese Acad Sci, Natl Lab Biomacromol, Beijing, Peoples R China 5.Chinese Acad Sci, Bioinformat Lab, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Lab, Bioinformat Res Grp,Key Lab Intelligent Informat, Beijing, Peoples R China 7.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Qi,Liu, Changning,Yuan, Xiongying,et al. Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network[J]. NUCLEIC ACIDS RESEARCH,2011,39(9):3864-3878. |
| APA | Liao, Qi.,Liu, Changning.,Yuan, Xiongying.,Kang, Shuli.,Miao, Ruoyu.,...&Zhao, Yi.(2011).Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network.NUCLEIC ACIDS RESEARCH,39(9),3864-3878. |
| MLA | Liao, Qi,et al."Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network".NUCLEIC ACIDS RESEARCH 39.9(2011):3864-3878. |
入库方式： OAI收割
来源：计算技术研究所
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