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Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System

文献类型：期刊论文

作者Liao, Qi1,2,3; Yuan, Xiongying3; Xiao, Hui3; Liu, Changning3; Lv, Zhiyue1,2; Zhao, Yi3; Wu, Zhongdao1,2
刊名PLOS ONE
出版日期2011-08-24
卷号6期号:8页码:11
ISSN号1932-6203
DOI10.1371/journal.pone.0023786
英文摘要Schistosoma japonicum is a major infectious agent of schistosomiasis. It has been reported that large number of proteins excreted and secreted by S. japonicum during its life cycle are important for its infection and survival in definitive hosts. These proteins can be used as ideal candidates for vaccines or drug targets. In this work, we analyzed the protein sequences of S. japonicum and found that compared with other proteins in S. japonicum, excretory/secretory (ES) proteins are generally longer, more likely to be stable and enzyme, more likely to contain immune-related binding peptides and more likely to be involved in regulation and metabolism processes. Based on the sequence difference between ES and non-ES proteins, we trained a support vector machine (SVM) with much higher accuracy than existing approaches. Using this SVM, we identified 191 new ES proteins in S. japonicum, and further predicted 7 potential interactions between these ES proteins and human immune proteins. Our results are useful to understand the pathogenesis of schistosomiasis and can serve as a new resource for vaccine or drug targets discovery for anti-schistosome.
资助项目National '973' project of China[2007CB513102] ; National Science Foundation of China[30972574] ; National Science Foundation of China[30771888] ; National Science Foundation of China[81000743] ; National Science Foundation of China[30800966]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000295832000060
出版者PUBLIC LIBRARY SCIENCE
源URL[http://119.78.100.204/handle/2XEOYT63/12975]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Liao, Qi
作者单位1.Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Liao, Qi,Yuan, Xiongying,Xiao, Hui,et al. Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System[J]. PLOS ONE,2011,6(8):11.
APA Liao, Qi.,Yuan, Xiongying.,Xiao, Hui.,Liu, Changning.,Lv, Zhiyue.,...&Wu, Zhongdao.(2011).Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System.PLOS ONE,6(8),11.
MLA Liao, Qi,et al."Identifying Schistosoma japonicum Excretory/Secretory Proteins and Their Interactions with Host Immune System".PLOS ONE 6.8(2011):11.

入库方式： OAI收割

来源：计算技术研究所

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