SiRNA designs to the crucial proteins of SARS coronavirus
文献类型：期刊论文
| 作者 | Zhang, Y; Xu, JY; Deng, W; Zhang, N; Cai, L; Zhao, Y; Bu, D; Chen, RS |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2003-06-01 |
| 卷号 | 30期号:3页码:335-338 |
| 关键词 | SARS coronavirus (SARS-CoV) RNA interference (RNAi) small interfering RNA (siRNA) bioinformatics |
| ISSN号 | 1000-3282 |
| 英文摘要 | RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is homologous in sequence to the silenced gene. In mammal cells, small interfering RNA (siRNA) duplexes can induce RNAi potently, which may provide a new approach to the therapeutics of certain diseases. Focusing on the five genes which coding five crucial proteins of SARS coronavirus(SARS-CoV) respectively, 348 siRNA candidate targets were obtained following bioinformatic methods. In theory, potent siRNA duplexes specifically suppress expression of their corresponding SARS-CoV target gene, while have no influence on the normal expression of human gene. It would lay a foundation for the further experimental researches on the siRNA-like drug design for the SARS-CoV. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000183733500002 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/13676]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China 2.Chinese Acad Sci, Bioinformat Lab, Inst Biophys, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Bioinformat Res Grp, Key Lab Intelligent Informat Proc, Comp Technol Inst, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Xu, JY,Deng, W,et al. SiRNA designs to the crucial proteins of SARS coronavirus[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(3):335-338. |
| APA | Zhang, Y.,Xu, JY.,Deng, W.,Zhang, N.,Cai, L.,...&Chen, RS.(2003).SiRNA designs to the crucial proteins of SARS coronavirus.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(3),335-338. |
| MLA | Zhang, Y,et al."SiRNA designs to the crucial proteins of SARS coronavirus".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.3(2003):335-338. |
入库方式： OAI收割
来源：计算技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。