Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis
文献类型：期刊论文
| 作者 | Qin, Xu-Jie1,2 ; Sun, Dong-Jie3; Ni, Wei1; Chen, Chang-Xiang1; Hua, Yan2; He, Li3; Liu, Hai-Yang1
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| 刊名 | STEROIDS
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| 出版日期 | 2012-10-01 |
| 卷号 | 77期号:12页码:1242-1248 |
| 关键词 | Paris polyphylla var. yunnanensis Trililiaceae Steroidal saponins Chonglouosides SL-1-SL-6 |
| ISSN号 | 0039-128X |
| 通讯作者 | Liu, HY (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,haiyangliu@mail.kib.ac.cn |
| 英文摘要 | Rhizoma Paridis, the root of Paris polyphylla var. yunnanensis (Trilliaceae), is a Chinese traditional medicine, which resources become less and less. However, the aerial parts of this herb, which can regenerate every year, were discarded. In order to expand the resources, detailed chemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis led to isolation of one sapogenin and 24 steroidal saponins (1-25). including 6 new glycosides, named chonglouosides SL-1-SL-6 (1-6). Their structures were elucidated on the basis of detailed analyses of their 1D and 2D NMR spectra and acid hydrolysis. Among them, compounds 3 and 4 are the first 23,27-dihydroxydiosgenin saponin having a sugar chain attached to C-23 or C-27, while compound 6 is the first 27-hydroxyruscogenin glycoside bearing 1, 27-di-O-sugar chains. The known compounds 10, 12, 14, 19, 20, 22, and 25 were isolated from the genus Paris for the first time. Antimicrobial testing activities of the selected compounds showed that compound 2, 3, 6, 8, 9, 11, 13, 17, 18, 21, and 24 were active against Propionibacterium acnes with MIC values of 62.5, 62.5, 3.9, 16.5, 17.2, 7.8, 39.0, 17.2, 31.3, 62.5, and 31.3 mu g/ml, respectively. (c) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Endocrinology & Metabolism |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | STRUCTURAL REQUIREMENT ; GLYCOSIDES ; SAPOGENINS ; RHIZOMES ; EXTRACT ; MODE |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Funding of China [31170333]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2008PY066]; Scientific and Technological Projects of Yunnan Province [2009AD013] |
| 语种 | 英语 |
| WOS记录号 | WOS:000310480800009 |
| 公开日期 | 2013-01-22 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/15950]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.SW Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China 3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Xu-Jie,Sun, Dong-Jie,Ni, Wei,et al. Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis[J]. STEROIDS,2012,77(12):1242-1248. |
| APA | Qin, Xu-Jie.,Sun, Dong-Jie.,Ni, Wei.,Chen, Chang-Xiang.,Hua, Yan.,...&Liu, Hai-Yang.(2012).Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis.STEROIDS,77(12),1242-1248. |
| MLA | Qin, Xu-Jie,et al."Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis".STEROIDS 77.12(2012):1242-1248. |
入库方式： OAI收割
来源：昆明植物研究所
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