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Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus

文献类型：期刊论文

作者Su, Yao2,3; Bi, Jun-Long1; Wang, Yue-Hu3; Tan, Ying3; Yang, Jun2,3; Liu, Hong-Xin3; Gu, Wei3; Yin, Ge-Fen1; Long, Chun-Lin3,4
刊名JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
出版日期2012-10-01
卷号23期号:10页码:1925-1932
ISSN号0103-5053
关键词Gesneriaceae quinines porcine reproductive and respiratory syndrome virus Chirita longgangensis var. hongyao
通讯作者Yin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China.,yingefen383@sohu.com ; long@mail.kib.ac.cn
英文摘要Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively.
学科主题Chemistry, Multidisciplinary
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CYTOTOXIC ANTHRAQUINONES ; TETRAZOLIUM SALT ; QUINONES ; NAPHTHOQUINONES ; REPLICATION ; EBURNEA ; AGENTS ; ROOTS ; ACID
资助信息National Natural Science Foundation of China [31070288, 20972166, 31160509, 31161140345]; Yunnan Provincial Program for Excellent Scientists [2009CI125]; Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]
收录类别SCI ; IC
语种英语
WOS记录号WOS:000312199200023
公开日期2013-01-22
源URL[http://ir.kib.ac.cn/handle/151853/15996]  
专题昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714		 Su, Yao,Bi, Jun-Long,Wang, Yue-Hu,et al. Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932.
APA Su, Yao.,Bi, Jun-Long.,Wang, Yue-Hu.,Tan, Ying.,Yang, Jun.,...&Long, Chun-Lin.(2012).Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,23(10),1925-1932.
MLA Su, Yao,et al."Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 23.10(2012):1925-1932.

入库方式： OAI收割

来源：昆明植物研究所

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