Synthesis of a novel ruthenium(II) complex and its unique behaviors in enzymatic dynamic kinetic resolution of secondary alcohols
文献类型：期刊论文
| 作者 | Chen QH(陈其辉) ; Yuan CY(袁承业) |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2010 |
| 卷号 | 66期号:21页码:3707-3716 |
| 其他题名 | Synthesis of a novel ruthenium(II) complex and its unique behaviors in enzymatic dynamic kinetic resolution of secondary alcohols |
| 通讯作者 | 袁承业 |
| 英文摘要 | A cyclopentadienyl benzoyl ruthenium(II) complex 3 was first prepared as an efficient catalyst in Candida Antarctica lipase B (CALB) mediated dynamic kinetic resolution (DKR) of secondary alcohols. With the aid of this ruthenium complex 3, (S)-1-phenylethanol was completely racemized within 25 min, and in combination with CALB, series of secondary alcohols bearing various functional groups were resolved in an efficient DKR manner. A detailed mechanism involving the C-H bond activation was presented for the formation of complex 3 by capturing the crucial intermediate in this pathway. Related mechanistic studies were carried out to illustrate this type of DKR catalyst is based on the racemization of secondary alcohols. The novelty of its structure, its unique catalytic behavior as well as its wide scope of application of various substrates and its higher efficiency make complex 3 as an important alternative to those complexes, which are commonly used in DKR process. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tet.2010.03.069 |
| 语种 | 英语 |
| WOS记录号 | WOS:000278196300011 |
| 公开日期 | 2013-01-09 |
| 源URL | [http://202.127.28.38/handle/331003/11084]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Chen QH,Yuan CY. Synthesis of a novel ruthenium(II) complex and its unique behaviors in enzymatic dynamic kinetic resolution of secondary alcohols[J]. Tetrahedron,2010,66(21):3707-3716. |
| APA | Chen QH,&Yuan CY.(2010).Synthesis of a novel ruthenium(II) complex and its unique behaviors in enzymatic dynamic kinetic resolution of secondary alcohols.Tetrahedron,66(21),3707-3716. |
| MLA | Chen QH,et al."Synthesis of a novel ruthenium(II) complex and its unique behaviors in enzymatic dynamic kinetic resolution of secondary alcohols".Tetrahedron 66.21(2010):3707-3716. |
入库方式： OAI收割
来源：上海有机化学研究所
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