Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers
文献类型：期刊论文
| 作者 | Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业) |
| 刊名 | Bioorg. Med. Chem. Lett.
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:1页码:234-239 |
| 其他题名 | 细胞自吞噬诱导剂二苯基丁基哌啶的合成及构效关系研究 |
| 英文摘要 | A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and gamma-butyrolactone was also reported here. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.bmcl.2010.11.029 |
| 语种 | 英语 |
| WOS记录号 | WOS:000285544400045 |
| 公开日期 | 2013-01-09 |
| 源URL | [http://202.127.28.38/handle/331003/11086]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Chen G,Xia HG,Cai Y,et al. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers[J]. Bioorg. Med. Chem. Lett.,2011,21(1):234-239. |
| APA | Chen G,Xia HG,Cai Y,Ma DW,Yuan JY,&Yuan CY.(2011).Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.Bioorg. Med. Chem. Lett.,21(1),234-239. |
| MLA | Chen G,et al."Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers".Bioorg. Med. Chem. Lett. 21.1(2011):234-239. |
入库方式： OAI收割
来源：上海有机化学研究所
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