Solution structure of BmP01 from the venom of scorpion buthus martensii karsch
文献类型：期刊论文
| 作者 | Wu G(吴宫) ; Li YM(李医明) ; Wei DS(魏东升) ; He FH(何发虎) ; Jiang SK(江绍开) ; Hu GY(胡国圆) ; Wu HM(吴厚铭) |
| 刊名 | Biochem. Biophys. Res. Commun.
 |
| 出版日期 | 2000 |
| 卷号 | 276期号:3页码:1148-1154 |
| ISSN号 | 0006-291X |
| 其他题名 | 马氏钳蝎毒液的神经肽BmP01 的溶液结构 |
| 通讯作者 | 吴宫 ; 李医明 ; 何发虎 ; 江绍开 ; 吴厚铭 |
| 英文摘要 | From the venom of scorpion Buthus martensii Karsch, a short peptide (BmPO1, 29 amino acid resi-dues) was isolated and characterized as previously reported (Lebren, ft. IL, a at. (1997) Eur. J. Biochem. 245,457-464). It was shown to reduce 33% outward K~+ channel (hippocampal neurons) currents at 10 μM. The solution structure of BmPO1 was determined by 2D 1~H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmPO1 is composed of a short a-helix (Cys 3-Thr 12) and a two-stranded antiparallel β-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disuffide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting theα-helix and β-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison be-tween BmPO1 and its analogues are also presented. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1006/bbrc.2000.3435 |
| 语种 | 英语 |
| WOS记录号 | WOS:000089794300052 |
| 公开日期 | 2013-02-21 |
| 源URL | [http://202.127.28.38/handle/331003/17261]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Wu G,Li YM,Wei DS,et al. Solution structure of BmP01 from the venom of scorpion buthus martensii karsch[J]. Biochem. Biophys. Res. Commun.,2000,276(3):1148-1154. |
| APA | 吴宫.,李医明.,魏东升.,何发虎.,江绍开.,...&吴厚铭.(2000).Solution structure of BmP01 from the venom of scorpion buthus martensii karsch.Biochem. Biophys. Res. Commun.,276(3),1148-1154. |
| MLA | 吴宫,et al."Solution structure of BmP01 from the venom of scorpion buthus martensii karsch".Biochem. Biophys. Res. Commun. 276.3(2000):1148-1154. |
入库方式： OAI收割
来源：上海有机化学研究所
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