A practical high through-put continuous process for the synthesis of chiral cyanohydrins
文献类型：期刊论文
| 作者 | Chen PR(陈沛然) ; Han SQ(韩世清) ; Lin GQ(林国强) ; Li ZY(李祖义) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2002 |
| 卷号 | 67期号:23页码:8251-8253 |
| ISSN号 | 0022-3263 |
| 其他题名 | 一个合成手性氰腈醇的有效的高通量的流动相装置的设计 |
| 通讯作者 | 林国强 |
| 英文摘要 | A practical high through-put continuous processfor the synthesis of chiral cyanohydrins is reported. Pretreated almond meal (or other solid raw enzyme sources) was loaded in a column to form a reactor, to which were attached a supplying system to deliver a solution of substrate and HCN in solvent on one end and a collecting-separating system on the other end. Bycontrolling the flowing rate, optimal conditions were achieved for the hydrocyanation of various aromatic carboxaldehydes in a "micro-aqueous”medium to produce chiral cyanohydrins in high yields and high enantiomeric excess (ee) with high substrate/catalyst ratio. |
| 学科主题 | 有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo020432n |
| 语种 | 英语 |
| WOS记录号 | WOS:000179110400045 |
| 公开日期 | 2013-02-20 |
| 源URL | [http://202.127.28.38/handle/331003/16607]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen PR,Han SQ,Lin GQ,et al. A practical high through-put continuous process for the synthesis of chiral cyanohydrins[J]. J. Org. Chem.,2002,67(23):8251-8253. |
| APA | 陈沛然,韩世清,林国强,&李祖义.(2002).A practical high through-put continuous process for the synthesis of chiral cyanohydrins.J. Org. Chem.,67(23),8251-8253. |
| MLA | 陈沛然,et al."A practical high through-put continuous process for the synthesis of chiral cyanohydrins".J. Org. Chem. 67.23(2002):8251-8253. |
入库方式： OAI收割
来源：上海有机化学研究所
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