Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media
文献类型：期刊论文
| 作者 | YU HUILEI ; Xu JH(许建和) ; WANG YUXIAO ; Lu WY(卢文芽) ; Lin GQ(林国强) |
| 刊名 | J. Comb. Chem.
 |
| 出版日期 | 2008 |
| 卷号 | 10期号:1页码:79-87 |
| ISSN号 | 1520-4766 |
| 其他题名 | Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media |
| 通讯作者 | 许建和 |
| 英文摘要 | Glycoconjugates can be artificially synthesized by combinatorial biocatalysis. An example is given in this paper describing the construction of glycoconjugates array by using glycosidase and lipase in nonaqueous media. This array was started from glucose, with three aryl alcohols as the aglycone moiety of glycosides and five acids or esters as acyl donors for combinatorial acylation of glycosides, affording a three-dimensional array containing about 30 members with diverse structures. The array would be more abundant if more aglycones and acyl donors with other structures were filled in. Indeed, diverse classes of carbohydrates besides glucose can also be employed for generating diverse glycoconjugates due to their different roles in numerous physiological responses. The composition and distribution of the demonstration glycoconjugates array was detected and evaluated by HPLC-MS with electrospray ionization. And also, the distribution of the artificial array can be adjusted by changing the molar ratio of the auxiliary materials. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/cc7001606 |
| 语种 | 英语 |
| WOS记录号 | WOS:000252409800013 |
| 公开日期 | 2013-02-20 |
| 源URL | [http://202.127.28.38/handle/331003/16685]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | YU HUILEI,Xu JH,WANG YUXIAO,et al. Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media[J]. J. Comb. Chem.,2008,10(1):79-87. |
| APA | YU HUILEI,许建和,WANG YUXIAO,卢文芽,&林国强.(2008).Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media.J. Comb. Chem.,10(1),79-87. |
| MLA | YU HUILEI,et al."Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media".J. Comb. Chem. 10.1(2008):79-87. |
入库方式： OAI收割
来源：上海有机化学研究所
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