Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone
文献类型：期刊论文
| 作者 | Liu M(刘敏) ; Sun XW(孙兴文) ; Xu MH(徐明华) ; Lin GQ(林国强) |
| 刊名 | Chem.-Eur. J.
 |
| 出版日期 | 2009 |
| 卷号 | 15期号:39页码:10217-10224 |
| ISSN号 | 0947-6539 |
| 其他题名 | Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone |
| 通讯作者 | 徐明华 ; 林国强 |
| 英文摘要 | All efficient and convenient alpha-hydroxyallylation approach for the asymmetric synthesis of a variety of beta-amino-alpha-vinyl alcohols has been successfully developed A wide range of vinylic amino alcohol derivatives could be obtained in very rood yields and with excellent diastereomeric ratios of up to 991 in favor of anti isomers by highly diastereoselective Zn-promoted benzoyloxyallylation of chiral N-tert-butanesulfinyl imines with 3-bromopropenyl benzoate. at room temperature. Ill particular. excellent enantioinduction of the two new stereogenic centers was observed. with up to 98% cc The method provides it new route for the direct alpha-hydroxyallylation of imines ill a highly stereoselective manner. Moreover, the synthetic value of the Method has also been demonstrated by the most concise and straightforward synthesis of (-)-cytoxazone yet reported |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/chem.200900801 |
| 语种 | 英语 |
| WOS记录号 | WOS:000270854200032 |
| 公开日期 | 2013-02-20 |
| 源URL | [http://202.127.28.38/handle/331003/16689]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu M,Sun XW,Xu MH,et al. Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone[J]. Chem.-Eur. J.,2009,15(39):10217-10224. |
| APA | 刘敏,孙兴文,徐明华,&林国强.(2009).Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone.Chem.-Eur. J.,15(39),10217-10224. |
| MLA | 刘敏,et al."Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone".Chem.-Eur. J. 15.39(2009):10217-10224. |
入库方式： OAI收割
来源：上海有机化学研究所
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