One-Pot Synthesis of Chiral alpha-Methylene-gamma-lactams with Excellent Diastereoselectivities and Enantioselectivities
文献类型：期刊论文
| 作者 | SHEN AN ; Liu M(刘敏) ; JIA ZHENSHAN ; Xu MH(徐明华) ; Lin GQ(林国强) |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:22页码:5154-5157 |
| ISSN号 | 1523-7060 |
| 其他题名 | 一锅法高立体选择性合成手性α-甲烯基-γ-丁内酰胺 |
| 通讯作者 | 徐明华 ; 林国强 |
| 英文摘要 | An efficient one-pot asymmetric synthesis of highly substituted gamma-lactams containing a-methylene groups has been successfully developed. A wide range of gamma-lactams could be obtained in high yields with excellent diastereomeric ratios of up to 99:1 in favor of trans isomers. In particular, excellent enantioselectivities of the two newly formed stereogenic centers with up to 99% ee were observed. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol102148b |
| 语种 | 英语 |
| WOS记录号 | WOS:000284080400019 |
| 公开日期 | 2013-02-20 |
| 源URL | [http://202.127.28.38/handle/331003/16709]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | SHEN AN,Liu M,JIA ZHENSHAN,et al. One-Pot Synthesis of Chiral alpha-Methylene-gamma-lactams with Excellent Diastereoselectivities and Enantioselectivities[J]. Org. Lett.,2010,12(22):5154-5157. |
| APA | SHEN AN,刘敏,JIA ZHENSHAN,徐明华,&林国强.(2010).One-Pot Synthesis of Chiral alpha-Methylene-gamma-lactams with Excellent Diastereoselectivities and Enantioselectivities.Org. Lett.,12(22),5154-5157. |
| MLA | SHEN AN,et al."One-Pot Synthesis of Chiral alpha-Methylene-gamma-lactams with Excellent Diastereoselectivities and Enantioselectivities".Org. Lett. 12.22(2010):5154-5157. |
入库方式： OAI收割
来源：上海有机化学研究所
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