Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations
文献类型：期刊论文
| 作者 | Wang PY(王鹏远) ; Song LP(宋力平) ; Yi H(易海) ; Zhang M(张敏) ; Zhu SZ(朱仕正) ; Deng HM(邓红梅) ; Shao M(邵敏) |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2010 |
| 卷号 | 51期号:30页码:3975-3977 |
| ISSN号 | 0040-4039 |
| 其他题名 | 简便的一步法合成氟取代二氢吡喃衍生物及其进一步化学转化 |
| 通讯作者 | 宋力平 ; 朱仕正 |
| 英文摘要 | One-pot four-component reactions of aromatic aldehyde, Meldrum's acid, ethyl-4,4,4-trifluoro-1,3-dioxobutanoate, and ammonium acetate afford ethyl 2-hydroxy-6-oxo-4-aryl-2-(trifluoromethyl)piperidine-3-carboxylate in good yields. The one-pot four-component process consists of an initial Michael addition, and a subsequent intramolecular cyclization. The effect of solvents on the reaction efficiency and yield is briefly investigated. The structure of product is further confirmed by XRD analysis. Meanwhile, the further transformation of hemi-aminal moiety to the corresponding dehydrated product is also achieved under the mild reaction conditions. The possible mechanism for the formation of product is presented. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 有机氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2010.05.110 |
| 语种 | 英语 |
| WOS记录号 | WOS:000279817400029 |
| 公开日期 | 2013-01-18 |
| 源URL | [http://202.127.28.38/handle/331003/14488]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang PY,Song LP,Yi H,et al. Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations[J]. Tetrahedron Lett.,2010,51(30):3975-3977. |
| APA | 王鹏远.,宋力平.,易海.,张敏.,朱仕正.,...&邵敏.(2010).Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations.Tetrahedron Lett.,51(30),3975-3977. |
| MLA | 王鹏远,et al."Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations".Tetrahedron Lett. 51.30(2010):3975-3977. |
入库方式： OAI收割
来源：上海有机化学研究所
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