Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines
文献类型：期刊论文
| 作者 | Chen XY(陈先印) ; Qiu XL(邱小龙) ; Qing FL(卿凤翎) |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2008 |
| 卷号 | 64期号:10页码:2301-2306 |
| ISSN号 | 0040-4020 |
| 其他题名 | Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines |
| 通讯作者 | 卿凤翎 |
| 英文摘要 | An efficient method for the asymmetric synthesis of the trifluoromethylated propargylamines was described. Addition of lithium trifluoromethylacetylide, in situ prepared from lithium diisopropylamide and the 2-bromo-3,3,3-trifluoropropene, to various N-tert-butanesulfinyl imines provided a range of trifluoromethylated propargyl sulfinamides. Besides high yields and excellent diastereoselectivities, the additions featured that the diastereoselectivities could be reversed when polar or nonpolar solvent was used. Acidic cleavage of the tert-butanesulfinyl groups delivered highly optically pure trifluoromethylated propargylamines. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tet.2008.01.021 |
| 语种 | 英语 |
| WOS记录号 | WOS:000253432600002 |
| 公开日期 | 2013-02-22 |
| 源URL | [http://202.127.28.38/handle/331003/17645]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen XY,Qiu XL,Qing FL. Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines[J]. Tetrahedron,2008,64(10):2301-2306. |
| APA | 陈先印,邱小龙,&卿凤翎.(2008).Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines.Tetrahedron,64(10),2301-2306. |
| MLA | 陈先印,et al."Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines".Tetrahedron 64.10(2008):2301-2306. |
入库方式： OAI收割
来源：上海有机化学研究所
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