中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies

文献类型:期刊论文

作者Shi ZD(史震旦) ; Yang BH(杨炳辉) ; Zhao JJ(赵晶晶) ; Wu YL(吴毓林) ; Ji YY(季永镛) ; Ye M(叶敏)
刊名Bioorg. Med. Chem.
出版日期2002
卷号10期号:7页码:2171-2175
ISSN号0968-0896
其他题名单克隆抗体催化的萘普生乙酯对映体选择性水解
通讯作者杨炳辉 ; 吴毓林
英文摘要This report described that a hapten of racemic phosphonate 3 designed as the mimic of the transition state of hydrolysis of naproxen ethyl ester was successfully synthesized from easily available 2-zacetyl-6-methoxy-naphthalene 5. Then BALB/C mice were immunized and one of the monoclonal catalytic antibodies, N116-27, which enantioselectively accelerated the hydrolysis of the R-(-)-naproxen ethyl ester was give. The Michaelis-Menton parameter for the catalyzed reaction was K^M=6.67 mM and K^cat/K^uncat=5.8×10~4. This enantioselective result was explained by the fact that the R-isomer of rac-hapten was more immunogenic than the S-isomer.
学科主题生命有机化学
收录类别SCI
原文出处http://dx.doi.org/10.1016/S0968-0896(02)00074-3
语种英语
WOS记录号WOS:000175649900010
公开日期2013-01-17
源URL[http://202.127.28.38/handle/331003/14038]  
专题上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式
GB/T 7714
Shi ZD,Yang BH,Zhao JJ,et al. Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies[J]. Bioorg. Med. Chem.,2002,10(7):2171-2175.
APA 史震旦,杨炳辉,赵晶晶,吴毓林,季永镛,&叶敏.(2002).Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies.Bioorg. Med. Chem.,10(7),2171-2175.
MLA 史震旦,et al."Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies".Bioorg. Med. Chem. 10.7(2002):2171-2175.

入库方式: OAI收割

来源:上海有机化学研究所

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