Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies
文献类型：期刊论文
| 作者 | Shi ZD(史震旦) ; Yang BH(杨炳辉) ; Zhao JJ(赵晶晶) ; Wu YL(吴毓林) ; Ji YY(季永镛) ; Ye M(叶敏) |
| 刊名 | Bioorg. Med. Chem.
 |
| 出版日期 | 2002 |
| 卷号 | 10期号:7页码:2171-2175 |
| ISSN号 | 0968-0896 |
| 其他题名 | 单克隆抗体催化的萘普生乙酯对映体选择性水解 |
| 通讯作者 | 杨炳辉 ; 吴毓林 |
| 英文摘要 | This report described that a hapten of racemic phosphonate 3 designed as the mimic of the transition state of hydrolysis of naproxen ethyl ester was successfully synthesized from easily available 2-zacetyl-6-methoxy-naphthalene 5. Then BALB/C mice were immunized and one of the monoclonal catalytic antibodies, N116-27, which enantioselectively accelerated the hydrolysis of the R-(-)-naproxen ethyl ester was give. The Michaelis-Menton parameter for the catalyzed reaction was K^M=6.67 mM and K^cat/K^uncat=5.8×10~4. This enantioselective result was explained by the fact that the R-isomer of rac-hapten was more immunogenic than the S-isomer. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/S0968-0896(02)00074-3 |
| 语种 | 英语 |
| WOS记录号 | WOS:000175649900010 |
| 公开日期 | 2013-01-17 |
| 源URL | [http://202.127.28.38/handle/331003/14038]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shi ZD,Yang BH,Zhao JJ,et al. Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies[J]. Bioorg. Med. Chem.,2002,10(7):2171-2175. |
| APA | 史震旦,杨炳辉,赵晶晶,吴毓林,季永镛,&叶敏.(2002).Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies.Bioorg. Med. Chem.,10(7),2171-2175. |
| MLA | 史震旦,et al."Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies".Bioorg. Med. Chem. 10.7(2002):2171-2175. |
入库方式： OAI收割
来源：上海有机化学研究所
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