Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins
文献类型：期刊论文
| 作者 | Li, Li1,2; Xie, Ping1,2 |
| 刊名 | BIOMEDICAL AND ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 22期号:4页码:297-302 |
| ISSN号 | 0895-3988 |
| 关键词 | Antioxidant response Histopathological characteristics Liver Microcystins Fish |
| 通讯作者 | Li, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China |
| 中文摘要 | Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX. |
| 英文摘要 | Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD(50) (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX. |
| 学科主题 | Environmental Sciences; Public ; Environmental & Occupational Health |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences ; Public, Environmental & Occupational Health |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 关键词[WOS] | TROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LR ; LIVER ; FISH ; BIOACCUMULATION ; AERUGINOSA ; TOXICITY |
| 资助信息 | National Natural Science Foundation of China [30700077] |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269378300004 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/7606]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430070, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Li,Xie, Ping. Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(4):297-302. |
| APA | Li, Li,&Xie, Ping.(2009).Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,22(4),297-302. |
| MLA | Li, Li,et al."Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 22.4(2009):297-302. |
入库方式： OAI收割
来源：水生生物研究所
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