Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids
文献类型：期刊论文
| 作者 | Ma DW(马大为) ; Jiang YW(蒋咏文) ; Chen FP(陈芳萍) ; 宫丽KUN ; Ding K(丁克) ; Xu Y(许永) ; Wang RX(王任小) ; Ge AH(葛爱华) ; Ren J(任进) ; Jingya Li ; Li J(李佳) ; Ye QZ(叶其壮) |
| 刊名 | J. Med. Chem.
 |
| 出版日期 | 2006 |
| 卷号 | 49期号:2页码:456-458 |
| ISSN号 | 0022-2623 |
| 其他题名 | 金属基质蛋白异构酶的选择性抑制剂及利用取代的γ-酮基羧酸体内治疗肺气肿 |
| 通讯作者 | 马大为 |
| 英文摘要 | The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of gamma-keto carboxylic acids are described. Among nine MNIP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and - 12 with IC50 values between 0.20 and 1.51 mu M, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jm051101g |
| 语种 | 英语 |
| WOS记录号 | WOS:000234836200005 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15527]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ma DW,Jiang YW,Chen FP,et al. Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids[J]. J. Med. Chem.,2006,49(2):456-458. |
| APA | 马大为.,蒋咏文.,陈芳萍.,宫丽KUN.,丁克.,...&叶其壮.(2006).Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.J. Med. Chem.,49(2),456-458. |
| MLA | 马大为,et al."Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids".J. Med. Chem. 49.2(2006):456-458. |
入库方式： OAI收割
来源：上海有机化学研究所
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