Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases
文献类型：期刊论文
| 作者 | Sun W(孙威) ; Nikolovska-Coleska, Zaneta ; Qin DG(秦东光) ; Sun HY(孙海鹰) ; Yang, ChaoYie ; Bai,Longchuang ; Qiu, Su ; Wang Y(王优) ; Ma DW(马大为) ; Wang SM(王少萌) |
| 刊名 | J. Med. Chem.
 |
| 出版日期 | 2009 |
| 卷号 | 52期号:3页码:593-596 |
| ISSN号 | 0022-2623 |
| 其他题名 | Smac的有效非肽类似物的设计,合成及测定 |
| 通讯作者 | 马大为 ; 王少萌 |
| 英文摘要 | A series of new Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 10 binds to XIAP, cIAP-1, and cIAP-2 BIR3 proteins with K-i of 3.9, 0.37, and 0.25 nM, respectively. Compound 10 antagonizes XIAP in a cell-free functional assay and induces rapid cIAP-1 degradation in cancer cells. Compound 10 inhibits cell growth in the MDA-MB-231 cancer cell line with an IC50 of 8.9 nM. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jm801101z |
| 语种 | 英语 |
| WOS记录号 | WOS:000263142400002 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15617]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun W,Nikolovska-Coleska, Zaneta,Qin DG,et al. Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases[J]. J. Med. Chem.,2009,52(3):593-596. |
| APA | 孙威.,Nikolovska-Coleska, Zaneta.,秦东光.,孙海鹰.,Yang, ChaoYie.,...&王少萌.(2009).Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases.J. Med. Chem.,52(3),593-596. |
| MLA | 孙威,et al."Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases".J. Med. Chem. 52.3(2009):593-596. |
入库方式： OAI收割
来源：上海有机化学研究所
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