中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases

文献类型:期刊论文

作者Sun W(孙威) ; Nikolovska-Coleska, Zaneta ; Qin DG(秦东光) ; Sun HY(孙海鹰) ; Yang, ChaoYie ; Bai,Longchuang ; Qiu, Su ; Wang Y(王优) ; Ma DW(马大为) ; Wang SM(王少萌)
刊名J. Med. Chem.
出版日期2009
卷号52期号:3页码:593-596
ISSN号0022-2623
其他题名Smac的有效非肽类似物的设计,合成及测定
通讯作者马大为 ; 王少萌
英文摘要A series of new Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 10 binds to XIAP, cIAP-1, and cIAP-2 BIR3 proteins with K-i of 3.9, 0.37, and 0.25 nM, respectively. Compound 10 antagonizes XIAP in a cell-free functional assay and induces rapid cIAP-1 degradation in cancer cells. Compound 10 inhibits cell growth in the MDA-MB-231 cancer cell line with an IC50 of 8.9 nM.
学科主题生命有机化学
收录类别SCI
原文出处http://dx.doi.org/10.1021/jm801101z
语种英语
WOS记录号WOS:000263142400002
公开日期2013-02-19
源URL[http://202.127.28.38/handle/331003/15617]  
专题上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式
GB/T 7714
Sun W,Nikolovska-Coleska, Zaneta,Qin DG,et al. Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases[J]. J. Med. Chem.,2009,52(3):593-596.
APA 孙威.,Nikolovska-Coleska, Zaneta.,秦东光.,孙海鹰.,Yang, ChaoYie.,...&王少萌.(2009).Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases.J. Med. Chem.,52(3),593-596.
MLA 孙威,et al."Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases".J. Med. Chem. 52.3(2009):593-596.

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来源:上海有机化学研究所

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