Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents
文献类型：期刊论文
| 作者 | Li B(李本) ; JONES ERIC DALE ; ZHOU ENKUN ; LI CHEN ; BAYLIS DEAN CAMERON ; Yu SH(余尚海) ; Wang M(汪淼) ; HE XING ; COATES JONATHAN ALAN VICTOR ; RHODES DAVID IAN ; Pei G(裴刚) ; DEADMAN JOHN JOSEPH ; Xie X(谢欣) ; Ma DW(马大为) |
| 刊名 | Bioorg. Med. Chem. Lett.
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:14页码:4012-4014 |
| ISSN号 | 0960-894X |
| 其他题名 | 含1,3,3,4-四取代吡咯烷的CCR5受体拮抗剂的构效关系研究, 第一部分: N-取代基的调整 |
| 通讯作者 | DEADMAN JOHN JOSEPH ; 谢欣 ; 马大为 |
| 英文摘要 | A novel series of CCR5 antagonists has been identified, utilizing the lead, nifeviroc, which were further modified based on bioisosteric principles. Lead optimization was pursued by balancing potential toxicity and potency. Potent analogues with low toxic properties were successfully developed by formation of urea and amide bonds at the nitrogen at position 4- of the pyrrolidine ring. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.bmcl.2010.05.102 |
| 语种 | 英语 |
| WOS记录号 | WOS:000279258800002 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15645]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li B,JONES ERIC DALE,ZHOU ENKUN,et al. Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents[J]. Bioorg. Med. Chem. Lett.,2010,20(14):4012-4014. |
| APA | 李本.,JONES ERIC DALE.,ZHOU ENKUN.,LI CHEN.,BAYLIS DEAN CAMERON.,...&马大为.(2010).Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents.Bioorg. Med. Chem. Lett.,20(14),4012-4014. |
| MLA | 李本,et al."Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents".Bioorg. Med. Chem. Lett. 20.14(2010):4012-4014. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。