Titanium(IV) chloride and quaternary ammonium salt promoted baylis-hillman reaction
文献类型：期刊论文
| 作者 | Shi M(施敏) ; Feng YS(冯言枢) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2001 |
| 卷号 | 66期号:2页码:406-411 |
| 其他题名 | 四氯化钛和季胺盐促进的Baylis-Hillman 反应 |
| 通讯作者 | 施敏 |
| 英文摘要 | The Baylis-Hillman reaction of aldehyds with α， β－unsaturated ketones can be drastically affected by the reaction temperature and lewis bases. When the reaction was carried out at -78℃ using catalytic amounts of quaternary ammonium salts (R^4N+X-,X=Cl, Br, I) as lewis bases, in the presence of titanium (IV) chloride, the chlorinated aldol adduct 1 was obtained as the major product. Quaternary ammonium bromides and iodides (R^4N+X-,X=Cl, Br, I) have higher catalytic activity than corresponding chlorides (R^4N+Cl-). Quaternary ammonium fluorides (R^4N+F-) do not have activity at all. The amounts of Lewis acid and quaternary ammonium salts used affect the reaction rate and product. A plausible reaction mechanism is proposed. If the reaction was carried out at rate and product. A plausible reaction mechanism is proposed. If the reaction was carried out at room temperature (about 20℃ ) in the presence of titanium (IV) chloride and quaternary ammonium salts (R^4N+X-,X=Cl, Br, I) , the elimination product 3, derived from 1, was formed as the major product. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo0009853 |
| 语种 | 英语 |
| WOS记录号 | WOS:000166560600007 |
| 公开日期 | 2013-01-09 |
| 源URL | [http://202.127.28.38/handle/331003/9754]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shi M,Feng YS. Titanium(IV) chloride and quaternary ammonium salt promoted baylis-hillman reaction[J]. J. Org. Chem.,2001,66(2):406-411. |
| APA | Shi M,&Feng YS.(2001).Titanium(IV) chloride and quaternary ammonium salt promoted baylis-hillman reaction.J. Org. Chem.,66(2),406-411. |
| MLA | Shi M,et al."Titanium(IV) chloride and quaternary ammonium salt promoted baylis-hillman reaction".J. Org. Chem. 66.2(2001):406-411. |
入库方式： OAI收割
来源：上海有机化学研究所
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