Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells
文献类型：期刊论文
| 作者 | Hu, Xiaozhong1; Hu, Decong1; Xu, Ying2 |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 27期号:3页码:327-337 |
| 关键词 | PBDE-47 HBCDs Cytotoxic effects Complex exposure |
| ISSN号 | 1382-6689 |
| 通讯作者 | Hu, XZ, Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China |
| 中文摘要 | This study was designed to determine cytotoxic effects of PBDE-47 and HBCDs individually or with a mixture of both compounds exposure to Hep G2 cells. The results showed PBDE-47 and HBCDs induced increase of nitric oxide synthase (NOS) activity, release of NO. dissipation of mitochondria membrane potential and cell apoptosis. Exposure to HBCDs induced ROS formation. Moreover, preincubation with PTIO (NO scavanger) and N-acetylcysteine (ROS scavanger) partially reversed cytotoxic effects of these compounds. The possible mechanism is that PBDE-47 and HBCDs could boost generation of NO and/or ROS, impact mitochondria, and result in start-ups of apoptosis program. Cells exposed to mixture of both compounds and each of them showed non-apoptotic rate significant difference, but the combination of them caused more adverse effects on cells. These results Suggest that PBDE-47 and HBCDs in single and complex exposure have the cytotoxic activity of anti-proliferation and induction of apoptosis in tumor cells in vitro. (C) 2008 Elsevier B.V. All rights reserved. |
| 英文摘要 | This study was designed to determine cytotoxic effects of PBDE-47 and HBCDs individually or with a mixture of both compounds exposure to Hep G2 cells. The results showed PBDE-47 and HBCDs induced increase of nitric oxide synthase (NOS) activity, release of NO. dissipation of mitochondria membrane potential and cell apoptosis. Exposure to HBCDs induced ROS formation. Moreover, preincubation with PTIO (NO scavanger) and N-acetylcysteine (ROS scavanger) partially reversed cytotoxic effects of these compounds. The possible mechanism is that PBDE-47 and HBCDs could boost generation of NO and/or ROS, impact mitochondria, and result in start-ups of apoptosis program. Cells exposed to mixture of both compounds and each of them showed non-apoptotic rate significant difference, but the combination of them caused more adverse effects on cells. These results Suggest that PBDE-47 and HBCDs in single and complex exposure have the cytotoxic activity of anti-proliferation and induction of apoptosis in tumor cells in vitro. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences; Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | BROMINATED FLAME RETARDANTS ; CYTOCHROME-C RELEASE ; BREAST-CANCER CELLS ; NITRIC-OXIDE ; HL-60 CELLS ; IN-VITRO ; DEVELOPMENTAL EXPOSURE ; INDUCED APOPTOSIS ; MISGURNUS-ANGUILLICAUDATUS ; MITOCHONDRIAL-FUNCTION |
| 收录类别 | SCI |
| 资助信息 | National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] |
| 语种 | 英语 |
| WOS记录号 | WOS:000265479000004 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/7772]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiaozhong,Hu, Decong,Xu, Ying. Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):327-337. |
| APA | Hu, Xiaozhong,Hu, Decong,&Xu, Ying.(2009).Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(3),327-337. |
| MLA | Hu, Xiaozhong,et al."Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.3(2009):327-337. |
入库方式： OAI收割
来源：水生生物研究所
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