中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Toxicological Research on Environmental Endocrine Disruptors

文献类型:期刊论文

作者Shi Xiongjie; Liu Chunsheng; Yu Ke; Deng Jun; Yu Liqin; Zhou Bingsheng
刊名PROGRESS IN CHEMISTRY
出版日期2009-03-01
卷号21期号:2-3页码:340-349
关键词endocrine disruptors endocrine system risk assessment toxicology
ISSN号1005-281X
通讯作者Shi, XJ, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
中文摘要Most evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalarnic-pituitary-gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic-pituitary-thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxicomics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action.
英文摘要Most evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalarnic-pituitary-gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic-pituitary-thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxicomics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action.
WOS标题词Science & Technology ; Physical Sciences
学科主题Chemistry ; Multidisciplinary
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]PITUITARY-GONADAL AXIS ; ZEBRAFISH DANIO-RERIO ; STEROIDOGENIC GENE-EXPRESSION ; H295R CELL-LINE ; TRANSGENIC MEDAKA ; HORMONE PRODUCTION ; PBDE METABOLITES ; AQUATIC HYPOXIA ; TELEOST FISH ; PCR ARRAY
收录类别SCI
语种英语
WOS记录号WOS:000264790400007
公开日期2010-10-13
源URL[http://ir.ihb.ac.cn/handle/152342/7800]  
专题水生生物研究所_中科院水生所知识产出(2009年前)_期刊论文
作者单位Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714
Shi Xiongjie,Liu Chunsheng,Yu Ke,et al. Toxicological Research on Environmental Endocrine Disruptors[J]. PROGRESS IN CHEMISTRY,2009,21(2-3):340-349.
APA Shi Xiongjie,Liu Chunsheng,Yu Ke,Deng Jun,Yu Liqin,&Zhou Bingsheng.(2009).Toxicological Research on Environmental Endocrine Disruptors.PROGRESS IN CHEMISTRY,21(2-3),340-349.
MLA Shi Xiongjie,et al."Toxicological Research on Environmental Endocrine Disruptors".PROGRESS IN CHEMISTRY 21.2-3(2009):340-349.

入库方式: OAI收割

来源:水生生物研究所

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