Toxicological Research on Environmental Endocrine Disruptors
文献类型：期刊论文
| 作者 | Shi Xiongjie; Liu Chunsheng; Yu Ke; Deng Jun; Yu Liqin; Zhou Bingsheng |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2009-03-01 |
| 卷号 | 21期号:2-3页码:340-349 |
| 关键词 | endocrine disruptors endocrine system risk assessment toxicology |
| ISSN号 | 1005-281X |
| 通讯作者 | Shi, XJ, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 中文摘要 | Most evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalarnic-pituitary-gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic-pituitary-thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxicomics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action. |
| 英文摘要 | Most evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalarnic-pituitary-gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic-pituitary-thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxicomics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | Chemistry ; Multidisciplinary |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | PITUITARY-GONADAL AXIS ; ZEBRAFISH DANIO-RERIO ; STEROIDOGENIC GENE-EXPRESSION ; H295R CELL-LINE ; TRANSGENIC MEDAKA ; HORMONE PRODUCTION ; PBDE METABOLITES ; AQUATIC HYPOXIA ; TELEOST FISH ; PCR ARRAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264790400007 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/7800]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi Xiongjie,Liu Chunsheng,Yu Ke,et al. Toxicological Research on Environmental Endocrine Disruptors[J]. PROGRESS IN CHEMISTRY,2009,21(2-3):340-349. |
| APA | Shi Xiongjie,Liu Chunsheng,Yu Ke,Deng Jun,Yu Liqin,&Zhou Bingsheng.(2009).Toxicological Research on Environmental Endocrine Disruptors.PROGRESS IN CHEMISTRY,21(2-3),340-349. |
| MLA | Shi Xiongjie,et al."Toxicological Research on Environmental Endocrine Disruptors".PROGRESS IN CHEMISTRY 21.2-3(2009):340-349. |
入库方式： OAI收割
来源：水生生物研究所
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