中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins

文献类型:期刊论文

作者Zhao, Yanyan2; Xie, Ping1,2; Zhang, Xuezhen2
刊名ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
出版日期2009-03-01
卷号27期号:2页码:195-199
ISSN号1382-6689
关键词Microcystins Domestic rabbit Daily exposure Oxidative stress
通讯作者Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
中文摘要Oxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.
英文摘要Oxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.
学科主题Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
关键词[WOS]IN-VIVO ; LR ; HEPATOTOXICITY ; CYANOBACTERIA ; LIVER ; RATS ; MICE ; GLUTATHIONE ; APOPTOSIS ; ENZYMES
资助信息Huazhong Agriculture University ; National Natural Science Foundation of China [30530170]
收录类别SCI
语种英语
WOS记录号WOS:000264387200005
公开日期2010-10-13
源URL[http://ir.ihb.ac.cn/handle/152342/7820]  
专题水生生物研究所_中科院水生所知识产出(2009年前)_期刊论文
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yanyan,Xie, Ping,Zhang, Xuezhen. Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(2):195-199.
APA Zhao, Yanyan,Xie, Ping,&Zhang, Xuezhen.(2009).Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(2),195-199.
MLA Zhao, Yanyan,et al."Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.2(2009):195-199.

入库方式: OAI收割

来源:水生生物研究所

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