中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins

文献类型:期刊论文

AuthorZhao, Yanyan2; Xie, Ping1,2; Zhang, Xuezhen2
SourceENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Issued Date2009-03-01
Volume27Issue:2Pages:195-199
KeywordMicrocystins Domestic rabbit Daily exposure Oxidative stress
ISSN1382-6689
Corresponding AuthorXie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
AbstractOxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.
English AbstractOxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
SubjectEnvironmental Sciences; Pharmacology & Pharmacy; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS Subject ExtendedEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS Keyword PlusIN-VIVO ; LR ; HEPATOTOXICITY ; CYANOBACTERIA ; LIVER ; RATS ; MICE ; GLUTATHIONE ; APOPTOSIS ; ENZYMES
SponsorshipHuazhong Agriculture University ; National Natural Science Foundation of China [30530170]
Indexed TypeSCI
Language英语
WOS IDWOS:000264387200005
Available Date2010-10-13