PdCl2-catalyzed efficient transformation of propargylic amines to (E)-alpha-chloroalkylidene-beta-lactams
文献类型：期刊论文
| 作者 | Ma SM(麻生明) ; Wu B(吴滨) ; Jiang XF(姜雪峰) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2005 |
| 卷号 | 70期号:7页码:2588-2593 |
| ISSN号 | 0022-3263 |
| 其他题名 | PdCl2-catalyzed efficient transformation of propargylic amines to (E)-alpha-chloroalkylidene-beta-lactams |
| 通讯作者 | 麻生明 |
| 英文摘要 | The PdCl2-catalyzed cyclocarbonylation reaction of propargylic amines with CuCl2 and benzoquinone afforded (E)-alpha-chloroalkylidene-beta-lactams in moderate to good yields. The formation of the corresponding Z-isomers or five-membered products was not observed. The reaction of the readily available optically active propargylic amines provides a convenient synthesis of the corresponding (E)-alpha-chloroalkylidene-beta-lactams with high ee values. The structure and the stereochemistry of the products were established by the X-ray single-crystal diffraction study of (E)-6d and (E)-6e, which indicates that the stereoselectivity in this reaction is different from what was observed with propargylic alcohols. A rationale for this reaction was proposed. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo0480996 |
| 语种 | 英语 |
| WOS记录号 | WOS:000227928200021 |
| 公开日期 | 2013-01-16 |
| 源URL | [http://202.127.28.38/handle/331003/12026]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ma SM,Wu B,Jiang XF. PdCl2-catalyzed efficient transformation of propargylic amines to (E)-alpha-chloroalkylidene-beta-lactams[J]. J. Org. Chem.,2005,70(7):2588-2593. |
| APA | 麻生明,吴滨,&姜雪峰.(2005).PdCl2-catalyzed efficient transformation of propargylic amines to (E)-alpha-chloroalkylidene-beta-lactams.J. Org. Chem.,70(7),2588-2593. |
| MLA | 麻生明,et al."PdCl2-catalyzed efficient transformation of propargylic amines to (E)-alpha-chloroalkylidene-beta-lactams".J. Org. Chem. 70.7(2005):2588-2593. |
入库方式： OAI收割
来源：上海有机化学研究所
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