Palladium(II)-catalyzed asymmetric synthesis of (Z)-alpha-alkylidene-gamma-butyrolactams from (Z)-N-allylic 2-alkynamides. Total synthesis of (-)-isocynometrine
文献类型：期刊论文
| 作者 | Xu Y(许蔚) ; Kong AD(孔爱娣) ; Lu XY(陆熙炎) |
| 刊名 | J. Org. Chem.
 |
| 出版日期 | 2006 |
| 卷号 | 71期号:10页码:3854-3858 |
| ISSN号 | 0022-3263 |
| 其他题名 | 钯(II)-催化的从(Z)-(N-烯丙基)2-炔酰胺不对称合成(Z)-a-亚烷基-g-丁内酯。 (-)-isocynometrine的全合成 |
| 通讯作者 | 陆熙炎 |
| 英文摘要 | Pd(OAc)(2) combined with nitrogen-containing ligands catalyzed the cyclization of (Z)-N-allylic 2-alkynamides in acetic acid to afford the alpha-(Z)-acetoxyalkylidene-gamma-butyrolactams in high yield and high stereoselectivity. When chiral nitrogen-containing ligands were used, the catalytic asymmetric protocol was achieved with moderate enantioselectivity (up to 80 degrees C). The utility of this new methodology was exemplified by the total synthesis of (-)-isocynometrine. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jo060288w |
| 语种 | 英语 |
| WOS记录号 | WOS:000237417400024 |
| 公开日期 | 2013-01-22 |
| 源URL | [http://202.127.28.38/handle/331003/14846]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu Y,Kong AD,Lu XY. Palladium(II)-catalyzed asymmetric synthesis of (Z)-alpha-alkylidene-gamma-butyrolactams from (Z)-N-allylic 2-alkynamides. Total synthesis of (-)-isocynometrine[J]. J. Org. Chem.,2006,71(10):3854-3858. |
| APA | 许蔚,孔爱娣,&陆熙炎.(2006).Palladium(II)-catalyzed asymmetric synthesis of (Z)-alpha-alkylidene-gamma-butyrolactams from (Z)-N-allylic 2-alkynamides. Total synthesis of (-)-isocynometrine.J. Org. Chem.,71(10),3854-3858. |
| MLA | 许蔚,et al."Palladium(II)-catalyzed asymmetric synthesis of (Z)-alpha-alkylidene-gamma-butyrolactams from (Z)-N-allylic 2-alkynamides. Total synthesis of (-)-isocynometrine".J. Org. Chem. 71.10(2006):3854-3858. |
入库方式： OAI收割
来源：上海有机化学研究所
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