Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp
文献类型：期刊论文
| 作者 | Li, Li1,2; Xie, Ping1; Guo, Longgen1; Ke, Zhixin1; Zhou, Qiong1; Liu, Yaqin1; Qiu, Tong1 |
| 刊名 | THESCIENTIFICWORLDJOURNAL
 |
| 出版日期 | 2008 |
| 卷号 | 8期号:0页码:121-137 |
| 关键词 | phytoplanktivorous bighead carp Microcystis blooms microcystin liver kidney pathological and biochemical characterizations large fish pen |
| ISSN号 | 1537-744X |
| 通讯作者 | Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 中文摘要 | Field and experimental studies were conducted to investigate pathological characterizations and biochemical responses in the liver and kidney of the phytoplanktivorous bighead carp after intraperitoneal (i.p.) administration of microcystins (MCs) and exposure to natural cyanobacterial blooms in Meiliang Bay, Lake Taihu. Bighead carp in field and laboratory studies showed a progressive recovery of structure and function in terms of histological, cellular, and biochemical features. In laboratory study, when fish were i.p. injected with extracted MCs at the doses of 200 and 500 mu g MC- LReq/kg body weight, respectively, liver pathology in bighead carp was observed in a time dose-dependent manner within 24 h postinjection and characterized by disruption of liver structure, condensed cytoplasm, and the appearance of massive hepatocytes with karyopyknosis, karyorrhexis, and karyolysis. In comparison with previous studies on other fish, bighead carp in field study endured higher MC doses and longer-term exposure, but displayed less damage in the liver and kidney. Ultrastructural examination in the liver revealed the presence of lysosome proliferation, suggesting that bighead carp might eliminate or lessen cell damage caused by MCs through lysosome activation. Biochemically, sensitive responses in the antioxidant enzymes and higher basal glutathione concentrations might be responsible for their powerful resistance to MCs, suggesting that bighead carp can be used as biomanipulation fish to counteract cyanotoxin contamination. |
| 英文摘要 | Field and experimental studies were conducted to investigate pathological characterizations and biochemical responses in the liver and kidney of the phytoplanktivorous bighead carp after intraperitoneal (i.p.) administration of microcystins (MCs) and exposure to natural cyanobacterial blooms in Meiliang Bay, Lake Taihu. Bighead carp in field and laboratory studies showed a progressive recovery of structure and function in terms of histological, cellular, and biochemical features. In laboratory study, when fish were i.p. injected with extracted MCs at the doses of 200 and 500 mu g MC- LReq/kg body weight, respectively, liver pathology in bighead carp was observed in a time dose-dependent manner within 24 h postinjection and characterized by disruption of liver structure, condensed cytoplasm, and the appearance of massive hepatocytes with karyopyknosis, karyorrhexis, and karyolysis. In comparison with previous studies on other fish, bighead carp in field study endured higher MC doses and longer-term exposure, but displayed less damage in the liver and kidney. Ultrastructural examination in the liver revealed the presence of lysosome proliferation, suggesting that bighead carp might eliminate or lessen cell damage caused by MCs through lysosome activation. Biochemically, sensitive responses in the antioxidant enzymes and higher basal glutathione concentrations might be responsible for their powerful resistance to MCs, suggesting that bighead carp can be used as biomanipulation fish to counteract cyanotoxin contamination. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences; Multidisciplinary Sciences |
| 类目[WOS] | Environmental Sciences ; Multidisciplinary Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Science & Technology - Other Topics |
| 关键词[WOS] | TROUT ONCORHYNCHUS-MYKISS ; GLUTATHIONE S-TRANSFERASES ; CYCLIC PEPTIDE TOXIN ; CARASSIUS-AURATUS L ; FISH DANIO-RERIO ; OXIDATIVE STRESS ; CYPRINUS-CARPIO ; RAINBOW-TROUT ; CYANOBACTERIA EXTRACT ; LIPID-PEROXIDATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254985000012 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/8162]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Li,Xie, Ping,Guo, Longgen,et al. Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp[J]. THESCIENTIFICWORLDJOURNAL,2008,8(0):121-137. |
| APA | Li, Li.,Xie, Ping.,Guo, Longgen.,Ke, Zhixin.,Zhou, Qiong.,...&Qiu, Tong.(2008).Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp.THESCIENTIFICWORLDJOURNAL,8(0),121-137. |
| MLA | Li, Li,et al."Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp".THESCIENTIFICWORLDJOURNAL 8.0(2008):121-137. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。