Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins
文献类型：期刊论文
| 作者 | Lei, Hehua1; Xie, Ping1; Chen, Jun1; Liang, Gaodao1; Dai, Ming1; Zhang, Xuezhen2 |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 27期号:5页码:1167-1174 |
| 关键词 | microcystins intraperitoneal injection Crucian carp tissue distribution depuration |
| ISSN号 | 0730-7268 |
| 通讯作者 | Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China |
| 中文摘要 | An acute toxicity experiment was conducted to examine the distribution and depuration of microcystins (MCS) in crucian carp (Carassius aurutus) tissues. Fish were injected intraperitoneally with extracted MCs at a dose of 200 mu g MC-LR (where L = leucine and R = arginine) equivalent/kg body weight. Microcystin concentrations in various tissues and aquaria water were analyzed at 1, 3, 12, 24, and 48 h postinjection using liquid chromatography coupled with mass spectrometry. Microcystins were detected mainly in blood (3.99% of injected dose at 1 h), liver (1.60% at I h), gonad (1.49% at 3 h), and kidney (0.14% at 48 h). Other tissues, such as the heart, gill, gallbladder, intestine, spleen, brain, and muscle, contained less than 0.1% of the injected MCs. The highest concentration of MCs was found in blood (526-3,753 ng/g dry wt), followed by liver (103-1,656 ng/g dry wt) and kidney (279-1,592 ng/g dry wt). No MC-LR was detectable in intestine, spleen, kidney, brain, and muscle, whereas MC-RR was found in all examined fish tissues, which might result from organ specificity of different MCs. Clearance of MC-RR in brain tissue was slow. In kidney, the MC-RR content was negatively correlated with that in blood, suggesting that blood was important in the transportation of MC-RR to kidney for excretion. |
| 英文摘要 | An acute toxicity experiment was conducted to examine the distribution and depuration of microcystins (MCS) in crucian carp (Carassius aurutus) tissues. Fish were injected intraperitoneally with extracted MCs at a dose of 200 mu g MC-LR (where L = leucine and R = arginine) equivalent/kg body weight. Microcystin concentrations in various tissues and aquaria water were analyzed at 1, 3, 12, 24, and 48 h postinjection using liquid chromatography coupled with mass spectrometry. Microcystins were detected mainly in blood (3.99% of injected dose at 1 h), liver (1.60% at I h), gonad (1.49% at 3 h), and kidney (0.14% at 48 h). Other tissues, such as the heart, gill, gallbladder, intestine, spleen, brain, and muscle, contained less than 0.1% of the injected MCs. The highest concentration of MCs was found in blood (526-3,753 ng/g dry wt), followed by liver (103-1,656 ng/g dry wt) and kidney (279-1,592 ng/g dry wt). No MC-LR was detectable in intestine, spleen, kidney, brain, and muscle, whereas MC-RR was found in all examined fish tissues, which might result from organ specificity of different MCs. Clearance of MC-RR in brain tissue was slow. In kidney, the MC-RR content was negatively correlated with that in blood, suggesting that blood was important in the transportation of MC-RR to kidney for excretion. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Environmental Sciences; Toxicology |
| 类目[WOS] | Environmental Sciences ; Toxicology |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
| 关键词[WOS] | TROUT ONCORHYNCHUS-MYKISS ; PHYTOPLANKTIVOROUS SILVER CARP ; FRESH-WATER SNAIL ; RAINBOW-TROUT ; EUTROPHIC LAKE ; DANIO-RERIO ; BIOCHEMICAL-CHARACTERIZATION ; CORYDORAS-PALEATUS ; SEASONAL DYNAMICS ; SUBTROPICAL CHINA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255063700021 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/8172]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Hehua,Xie, Ping,Chen, Jun,et al. Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2008,27(5):1167-1174. |
| APA | Lei, Hehua,Xie, Ping,Chen, Jun,Liang, Gaodao,Dai, Ming,&Zhang, Xuezhen.(2008).Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,27(5),1167-1174. |
| MLA | Lei, Hehua,et al."Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 27.5(2008):1167-1174. |
入库方式： OAI收割
来源：水生生物研究所
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