Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)
文献类型：期刊论文
| 作者 | Zhang, Xuezhen2; Xie, Ping1,2; Wang, Weimin2; Li, Dapeng1,2; Li, Li1,2; Tang, Rong1,2; Lei, Hehua1; Shi, Zechao3 |
| 刊名 | TOXICON
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 51期号:3页码:449-456 |
| 关键词 | microcystins crude extract southern catfish embryonic development larval growth histopathological changes |
| ISSN号 | 0041-0101 |
| 通讯作者 | Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China |
| 中文摘要 | A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved. |
| 英文摘要 | A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | CARP CYPRINUS-CARPIO ; ZEBRAFISH DANIO-RERIO ; CYANOBACTERIAL TOXINS ; CARASSIUS-AURATUS ; ORYZIAS-LATIPES ; CRUDE EXTRACTS ; LR ; FISH ; TOXICITY ; ACCUMULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254369600014 |
| 公开日期 | 2010-10-13 |
| 源URL | [http://ir.ihb.ac.cn/handle/152342/8202]  |
| 专题 | 水生生物研究所_中科院水生所知识产出（2009年前）_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Minist Educ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China 3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xuezhen,Xie, Ping,Wang, Weimin,et al. Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)[J]. TOXICON,2008,51(3):449-456. |
| APA | Zhang, Xuezhen.,Xie, Ping.,Wang, Weimin.,Li, Dapeng.,Li, Li.,...&Shi, Zechao.(2008).Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis).TOXICON,51(3),449-456. |
| MLA | Zhang, Xuezhen,et al."Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)".TOXICON 51.3(2008):449-456. |
入库方式： OAI收割
来源：水生生物研究所
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