A Concise Synthesis of (-)-Indolizidines 209D and 209B
文献类型：期刊论文
| 作者 | Wu H(武豪) ; Yu ML(俞梦龙) ; Zhang YZ(张亚竹) ; Zhao G(赵刚) |
| 刊名 | Chin. J. Chem.
 |
| 出版日期 | 2009 |
| 卷号 | 27期号:1页码:183-188 |
| ISSN号 | 1001-604X |
| 其他题名 | 一种简洁合成(-)-Indolizidines 209D和209B |
| 通讯作者 | 赵刚 |
| 英文摘要 | A general stereoselective synthetic route to 5-substituted and 5,8-disubstituted indolizidine alkaloids has been developed starting from commercially available L-proline. (-)-Indolizidines 209D and 209B were efficiently synthesized in 9.8% and 14.8% overall yields in seven and five-step reactions from readily available aldehyde 3 and ketone 10, respectively. The key steps of this synthesis involve a substrate-induced asymmetric addition of ethyl lithiopropiolate to aldehyde 3 or methyl ketone 10. and a two-step one-pot hydrogenation/cyclization sequence to construct the bicyclic skeleton. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/cjoc.200990015 |
| 语种 | 英语 |
| WOS记录号 | WOS:000264039400031 |
| 公开日期 | 2013-02-26 |
| 源URL | [http://202.127.28.38/handle/331003/20767]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu H,Yu ML,Zhang YZ,et al. A Concise Synthesis of (-)-Indolizidines 209D and 209B[J]. Chin. J. Chem.,2009,27(1):183-188. |
| APA | 武豪,俞梦龙,张亚竹,&赵刚.(2009).A Concise Synthesis of (-)-Indolizidines 209D and 209B.Chin. J. Chem.,27(1),183-188. |
| MLA | 武豪,et al."A Concise Synthesis of (-)-Indolizidines 209D and 209B".Chin. J. Chem. 27.1(2009):183-188. |
入库方式： OAI收割
来源：上海有机化学研究所
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