Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
文献类型：期刊论文
| 作者 | LE GIANG ; VANDEGRAAFF NICK ; RHODES DAVID I ; JONES ERIC D ; COATES JONATHAN A V ; THIENTHONG NEERANAT ; WINFIELD LISA J ; Lv L(吕龙) ; LI XINMING ; YU CHANGJIANG ; FENG XIAO ; DEADMAN JOHN J |
| 刊名 | Bioorg. Med. Chem. Lett.
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:19页码:5909-5912 |
| ISSN号 | 0960-894X |
| 其他题名 | Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators |
| 通讯作者 | DEADMAN JOHN J |
| 英文摘要 | Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole as the most promising heterocycles. Initial SAR studies indicated that these novel series of integrase inhibitors are amenable to lead optimization. Several compounds with low nanomolar inhibitory potency are reported. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.bmcl.2010.07.081 |
| 语种 | 英语 |
| WOS记录号 | WOS:000281735600067 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/19229]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | LE GIANG,VANDEGRAAFF NICK,RHODES DAVID I,et al. Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators[J]. Bioorg. Med. Chem. Lett.,2010,20(19):5909-5912. |
| APA | LE GIANG.,VANDEGRAAFF NICK.,RHODES DAVID I.,JONES ERIC D.,COATES JONATHAN A V.,...&DEADMAN JOHN J.(2010).Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators.Bioorg. Med. Chem. Lett.,20(19),5909-5912. |
| MLA | LE GIANG,et al."Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators".Bioorg. Med. Chem. Lett. 20.19(2010):5909-5912. |
入库方式： OAI收割
来源：上海有机化学研究所
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